Coefficient estimates from repeated measures models for multivariate associations between categorised scale values of depression, happiness, life satisfaction and F3 promoter methylation (n=658 men, 988 observations)
| Coefficient estimate | 95% CI | p Value | |
|---|---|---|---|
| Depression | |||
| 0 | – | – | – |
| 0.01–0.4 | −0.13 | −0.34 to 0.09 | 0.24 |
| >0.4 | 0.33 | 0.10 to 0.56 | 0.005 |
| Ptrend =0.03 | |||
| Happiness | |||
| 1–4 (unhappy) | – | – | |
| 5–7 | −0.20 | −0.54 to 0.14 | 0.24 |
| 8–9 (happy) | −0.51 | −0.85 to −0.18 | 0.003 |
| Ptrend <0.001 | |||
| Life satisfaction | |||
| 0–5 | – | – | – |
| 6–8 | −0.28 | −0.49 to −0.06 | 0.01 |
| 9–11 | −0.40 | −0.60 to −0.20 | <0.001 |
| Ptrend <0.001 | |||
F3 methylation values corresponded to the average levels of methylation across CpG sites within the F3 promoter region.
All models adjusted for age, smoking status, educational attainment, history of CHD or stroke prior to 1999, history of diabetes prior to 1999, % basophils, % eosinophils, % lymphocytes, % monocytes, % neutrophils and plasma folate.
CHD, coronary heart disease; F3, coagulation factor III.