Coefficient estimates from repeated measures models for multivariate associations between categorised scale values of depression and happiness, and ICAM-1 promoter methylation (n=600 men, 906 observations)
| Coefficient estimate | 95% CI | p Value | |
|---|---|---|---|
| Depression | |||
| 0 | – | – | – |
| 0.01–0.4 | 0.19 | −0.16 to 0.55 | 0.29 |
| >0.4 | 0.30 | −0.09 to 0.70 | 0.13 |
| Ptrend =0.09 | |||
| Happiness | |||
| 1–4 (not happy) | – | – | – |
| 5–7 | −0.21 | −0.76 to 0.34 | 0.46 |
| 8–9 (happy) | −0.42 | −0.97 to 0.13 | 0.13 |
| Ptrend =0.06 | |||
ICAM-1 methylation values corresponded to the average levels of methylation across CpG sites within the ICAM-1 promoter region.
All models adjusted for age, smoking status, educational attainment, history of CHD or stroke prior to 1999, history of diabetes prior to 1999, % basophils, % eosinophils, % lymphocytes, % monocytes, % neutrophils and plasma folate.
CHD, coronary heart disease; ICAM-1, intercellular adhesion molecule-1.