RT Journal Article
SR Electronic
T1 Minimally important difference estimates and methods: a protocol
JF BMJ Open
JO BMJ Open
FD British Medical Journal Publishing Group
SP e007953
DO 10.1136/bmjopen-2015-007953
VO 5
IS 10
A1 Bradley C Johnston
A1 Shanil Ebrahim
A1 Alonso Carrasco-Labra
A1 Toshi A Furukawa
A1 Donald L Patrick
A1 Mark W Crawford
A1 Brenda R Hemmelgarn
A1 Holger J Schunemann
A1 Gordon H Guyatt
A1 Gihad Nesrallah
YR 2015
UL http://bmjopen.bmj.com/content/5/10/e007953.abstract
AB Introduction Patient-reported outcomes (PROs) are often the outcomes of greatest importance to patients. The minimally important difference (MID) provides a measure of the smallest change in the PRO that patients perceive as important. An anchor-based approach is the most appropriate method for MID determination. No study or database currently exists that provides all anchor-based MIDs associated with PRO instruments; nor are there any accepted standards for appraising the credibility of MID estimates. Our objectives are to complete a systematic survey of the literature to collect and characterise published anchor-based MIDs associated with PRO instruments used in evaluating the effects of interventions on chronic medical and psychiatric conditions and to assess their credibility.Methods and analysis We will search MEDLINE, EMBASE and PsycINFO (1989 to present) to identify studies addressing methods to estimate anchor-based MIDs of target PRO instruments or reporting empirical ascertainment of anchor-based MIDs. Teams of two reviewers will screen titles and abstracts, review full texts of citations, and extract relevant data. On the basis of findings from studies addressing methods to estimate anchor-based MIDs, we will summarise the available methods and develop an instrument addressing the credibility of empirically ascertained MIDs. We will evaluate the credibility of all studies reporting on the empirical ascertainment of anchor-based MIDs using the credibility instrument, and assess the instrument's inter-rater reliability. We will separately present reports for adult and paediatric populations.Ethics and dissemination No research ethics approval was required as we will be using aggregate data from published studies. Our work will summarise anchor-based methods available to establish MIDs, provide an instrument to assess the credibility of available MIDs, determine the reliability of that instrument, and provide a comprehensive compendium of published anchor-based MIDs associated with PRO instruments which will help improve the interpretability of outcome effects in systematic reviews and practice guidelines.