RT Journal Article SR Electronic T1 Lag time for retinoblastoma in the UK revisited: a retrospective analysis JF BMJ Open JO BMJ Open FD British Medical Journal Publishing Group SP e015625 DO 10.1136/bmjopen-2016-015625 VO 7 IS 7 A1 Marcus Posner A1 Adil Jaulim A1 Marina Vasalaki A1 Khadija Rantell A1 Mandeep S Sagoo A1 M Ashwin Reddy YR 2017 UL http://bmjopen.bmj.com/content/7/7/e015625.abstract AB Objectives To explore current delays in diagnosis of retinoblastoma (Rb) and effect on outcome with comparison to a study from the 1990s.Setting Primary, secondary, tertiary care: majority from South of England.Participants A retrospective analysis of 93 new referrals of sporadic (non-familial) Rb to a specialist Rb unit in London, UK from January 2006 to February 2014.Primary and secondary outcomes International Intraocular Retinoblastoma Classification, lag times including parental delay and healthcare professional delay, patients requiring enucleation and requirement of adjuvant chemotherapy postenucleation (high-risk Rb).Results During the study period, 29% presented via accident and emergency (A&E). The median referral time from symptom onset to visiting primary care (PC) was 28 days and PC to ophthalmologist 3 days (range 0–181 days). The median time from local ophthalmologist to the Rb Unit was 6 days (0–33). No significant correlation was found between delay and International Classification of Retinoblastoma grade (p>0.05) or between postenucleation adjuvant chemotherapy and enucleation groups (p>0.05). Less enucleations (60%) are being performed compared with the previous study (81%) (p=0.0015).Conclusions Parents are attending A&E more compared with the 1990s and this may reflect the effect of public awareness campaigns. More eyes are being salvaged despite a similar number of children requiring adjuvant chemotherapy. High-risk Rb and Group E eyes do not correlate with increased lag time in the UK. Other determinants such as tumour biology may be more relevant.