Original articleGeneral thoracicResection of Pulmonary and Extrapulmonary Sarcomatous Metastases Is Associated With Long-Term Survival
Section snippets
Patient Population
From 1998 to 2006, 15,744 patients with soft tissue and bone sarcoma were referred to The University of Texas M.D. Anderson Cancer Center. During this interval, 4,355 (27.7%) patients were diagnosed with sarcomatous pulmonary metastases. They received various combinations of treatment ranging from chemotherapy, radiotherapy, and surgery. Patients were referred for immediate surgery if they presented with a single pulmonary metastasis or a limited number of metastases and a long disease-free
Patient Characteristics and Histology
Out of 4,355 patients with sarcomatous pulmonary metastases, 234 (5.6%) patients were treated with pulmonary metastasectomy. The mean and median ages at diagnosis of primary sarcoma were 42.5 and 43 years, respectively, and the age range was 8 to 83 years. Of these, 123 (52.6%) were men and 111 (47.4%) were women. The frequency distribution and definition of the different resection groups is shown in Table 1. The frequency distribution of patient characteristics and primary histology according
Comment
Sarcomatous pulmonary metastasectomy remains the cornerstone for treatment of isolated pulmonary metastases. Resection of extrathoracic pulmonary metastases in conjunction with lung metastases has to this point not been evaluated. This single-institution review provides new prognostic indicators as well as an evaluation of a previously unvalidated treatment paradigm. Long-term survival can be achieved when a complete resection is possible for both pulmonary and extrapulmonary metastases.
The
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