ArticlesRandomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome
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Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary
2019, Clinical TherapeuticsCitation Excerpt :Although there have been a limited number of studies on the efficacy of antidepressants in treating ME/CFS, the findings have again been largely inconclusive and contradictory. A randomized, double-blind study on the effectiveness of the tricyclic MAO inhibitor fluoxetine in 96 participants found that a daily dosage of fluoxetine had no beneficial effect on the symptoms of ME/CFS.36 Neither depressed nor nondepressed patients with ME/CFS showed significant improvement, leading the investigators to conclude that depressive symptoms seen in ME/CFS may arise from unique mechanisms not shared by other depressive disorders.36
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