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Exercise for prevention and treatment of cardiovascular disease, type 2 diabetes, and metabolic syndrome

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Abstract

A considerable number of observational and intervention studies support the role of exercise as a cornerstone in prevention and treatment of cardiovascular disease (CVD), type 2 diabetes (T2D), and the metabolic syndrome. Physical activity and cardiorespiratory fitness are also associated with reduced mortality rates among persons with CVD, T2D, and metabolic syndrome. Exercise has definite acute effects on a number of risk markers for CVD and T2D, in addition to more substantial benefits with chronic training. Both aerobic and resistance exercise have therapeutic value, largely independent of weight loss, and should be included in exercise programs.

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References and Recommended Reading

  1. LaMonte MJ, Barlow CE, Jurca R, et al.: Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome. A prospective study of men and women. Circulation 2005, 112:505–512.

    Article  PubMed  Google Scholar 

  2. LaMonte MJ, Blair SN, Church TS: Physical activity and diabetes prevention. J Appl Physiol 2005, 99:1205–1213.

    Article  PubMed  Google Scholar 

  3. Bassuk SS, Manson JE: Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. J Appl Physiol 2005, 99:1193–1204.

    Article  PubMed  Google Scholar 

  4. Church TS, LaMonte MJ, Barlow CE, Blair SN: Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. Arch Intern Med 2005, 165:2114–2120.

    Article  PubMed  CAS  Google Scholar 

  5. Trichopoulou A, Psaltopoulou T, Orfanos P, Trichopoulos D: Diet and physical activity in relation to overall mortality amongst adult diabetics in a general population cohort. J Intern Med 2006, 259:583–591.

    Article  PubMed  CAS  Google Scholar 

  6. Jurca R, LaMonte MJ, Barlow CE, et al.: Association of muscular strength with incidence of metabolic syndrome in men. Med Sci Sports Exerc 2005, 35:1849–1855.

    Article  Google Scholar 

  7. Imperatore G, Cheng YJ, Williams DE, et al.: Physical activity, cardiovascular fitness, and insulin sensitivity among U.S. adolescents. Diabetes Care 2006, 29:1567–1572.

    Article  PubMed  Google Scholar 

  8. Morrato EH, Hill JO, Wyatt HR, et al.: Are health care professionals advising patients with diabetes or at risk for developing diabetes to exercise more? Diabetes Care 2006, 29:543–548.

    Article  PubMed  Google Scholar 

  9. Mayer-Davis EJ, D’Agostino R, Karter AJ, et al.: Intensity and amount of physical activity in relation to insulin sensitivity. The insulin resistance atherosclerosis study. JAMA 1998, 279:669–674.

    Article  PubMed  CAS  Google Scholar 

  10. Irwin ML, Mayer-Davis EJ, Addy CL, et al.: Moderate-intensity physical activity and fasting insulin levels in women. The Cross-Cultural Activity Participation Study. Diabetes Care 2000, 232:449–454.

    Article  Google Scholar 

  11. Rankinen T, Suomela-Markkanen T, Vaisanen S, et al.: Relationship between changes in physical activity and plasma insulin during a 2.5-year follow-up study. Metabolism 1997, 46:1418–1423.

    Article  PubMed  CAS  Google Scholar 

  12. Orakzai RH, Orakzai SH, Nasir K, et al.: Association of increased cardiorespiratory fitness with low risk for clustering of metabolic syndrome components in asymptomatic men. Arch Med Res 2006, 37:522–528.

    Article  PubMed  CAS  Google Scholar 

  13. Wei M, Gibbons LW, Mitchell TL, et al.: The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 1999, 130:89–96.

    PubMed  CAS  Google Scholar 

  14. Katzmarzyk PT, Church TS, Janssen I, et al.: Metabolic syndrome, obesity, and mortality. Diabetes Care 2005, 28:391–397.

    Article  PubMed  Google Scholar 

  15. Wei M, Gibbons LW, Kampert JB, et al.: Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes. Ann Intern Med 2000, 132:605–611.

    PubMed  CAS  Google Scholar 

  16. Pan XR, Li GW, Hu YH, et al.: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. Diabetes Care 1997, 20:537–544.

    Article  PubMed  CAS  Google Scholar 

  17. Tuomilehto J, Lindstrom J, Eriksson JG, et al.: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001, 344:1343–1350.

    Article  PubMed  CAS  Google Scholar 

  18. Knowler WC, Barrett-Connor E, Fowler SE, et al.: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, 346:393–403.

    Article  PubMed  CAS  Google Scholar 

  19. Orchard TJ, Temprosa M, Goldberg R, et al.: The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med 2005, 142:611–619.

    PubMed  CAS  Google Scholar 

  20. Aas AM, Seljeflot I, Torjesen PA, et al.: Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes. Diabetologia 2006, 49:872–880.

    Article  PubMed  CAS  Google Scholar 

  21. Okada K, Hayashita T, Tsumura K, et al.: Leisure-time physical activity at weekends and the risk of type 2 diabetes mellitus in Japanese men: the Osaka Health Survey. Diabet Med 2000, 17:53–58.

    Article  PubMed  CAS  Google Scholar 

  22. Gregg EW, Gerzoff RB, Casperson CJ, et al.: Relationship of walking to mortality among US adults with diabetes. Arch Intern Med 2003, 163:1440–1447.

    Article  PubMed  Google Scholar 

  23. Carroll S, Dudfield M: What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome. Sports Med 2004, 34:371–418.

    Article  PubMed  Google Scholar 

  24. Braith RW, Stewart KJ: Resistance exercise training. Its role in the prevention of cardiovascular disease. Circulation 2006, 113:2642–2650.

    Article  PubMed  Google Scholar 

  25. Woods JA, Viera VJ, Keylock KT: Exercise, inflammation, and innate immunity. Neurol Clin 2006, 24:585–599.

    Article  PubMed  Google Scholar 

  26. Niessner A, Richter B, Penka M, et al.: Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization? Atherosclerosis 2006, 186:160–165.

    Article  PubMed  CAS  Google Scholar 

  27. Thompson PD, Crouse SF, Goodpaster B, et al.: The acute versus the chronic response to exercise. Med Sci Sports Exerc 2001, 33:S438–S445.

    Article  PubMed  CAS  Google Scholar 

  28. Fritz T, Wandell P, Aberg H, Engfeldt: Walking for exercise—does three times per week influence risk factors in type 2 diabetes? Diabetes Res Clin Prac 2006, 71:21–27.

    Article  Google Scholar 

  29. Swain DP, Franklin BA: Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise. Am J Cardiol 2006, 97:141–147.

    Article  PubMed  Google Scholar 

  30. Slentz CA, Aiken LB, Houmard JA, et al.: Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol 2005, 99:1613–1618.

    Article  PubMed  Google Scholar 

  31. O’Leary VB, Marchetti CM, Krishnan RK, et al.: Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol 2006, 100:1584–1589.

    Article  PubMed  CAS  Google Scholar 

  32. DiPietro L, Dziura J, Yeckel C, Neufer PD: Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 2006, 100:142–149.

    Article  PubMed  CAS  Google Scholar 

  33. Houmard J, Tanner C, Slentz C, et al.: Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 2004, 96:101–106.

    Article  PubMed  CAS  Google Scholar 

  34. Ferrara CM, Goldberg AP, Ortmeyer HK, Ryan AS: Effects of aerobic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older men. J Gerontol A Biol Sci Med Sci 2006, 61:480–487.

    PubMed  Google Scholar 

  35. Olson TP, Dengel DR, Leon AS, Schmitz KH: Moderate resistance training and vascular health in overweight women. Med Sci Sports Exerc 2006, 38:1558–1564.

    Article  PubMed  Google Scholar 

  36. Gokce N, Keaney JF, Hunter LM, et al.: Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function. Circulation 2002, 105:1567–1572.

    Article  PubMed  Google Scholar 

  37. Widlansky ME, Gokce N, Keaney JF, Vita JF: Then clinical implications of endothelial function. J Am Coll Cardiol 2003, 42:1149–1160.

    Article  PubMed  CAS  Google Scholar 

  38. Shaibi GQ, Cruz ML, Ball GD, et al.: Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc 2006, 38:1208–1215.

    Article  PubMed  CAS  Google Scholar 

  39. Stewart KJ, Bacher AC, Turner K, et al.: Exercise and risk factors associated with metabolic syndrome in older adults. Am J Prev Med 2005, 28:9–18.

    Article  PubMed  Google Scholar 

  40. Wagner H, Degerblad M, Thorell A, et al.: Combined treatment with exercise training and acarbose improves metabolic control and cardiovascular risk factor profile in subjects with mild type 2 diabetes. Diabetes Care 2006, 29:1471–1477.

    Article  PubMed  CAS  Google Scholar 

  41. Weinstein AR, Sesso HD: Joint effects of physical activity and body weight on diabetes and cardiovascular disease. Exerc Sport Sci Rev 2006, 34:10–15.

    Article  PubMed  Google Scholar 

  42. Anderson JW, Konz EC, Frederich RC, Wood CL: Long-term weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr 2001, 74:579–584.

    PubMed  CAS  Google Scholar 

  43. Boule NG, Weisnagel SJ, Lakka TA, et al.: Effects of exercise training on glucose homeostasis. Diabetes Care 2005, 28:120–126.

    Article  Google Scholar 

  44. Marsoobian V, Grosvenor M, Jacobs M, Ipp E: Very-low-energy diets alter the counterregulatory response to falling plasma glucose concentrations. Am J Clin Nutr 1995, 61:373–378.

    PubMed  CAS  Google Scholar 

  45. Pate RR, Pratt M, Blair SN, et al.: Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995, 273:402–407.

    Article  PubMed  CAS  Google Scholar 

  46. American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults [no authors listed]. Med Sci Sports Exerc 1998, 30:975–991.

    Article  Google Scholar 

  47. American College of Sports Medicine Position Stand. Exercise and type 2 diabetes [no authors listed]. Med Sci Sports Exerc 2000, 32:1345–1360.

    Article  Google Scholar 

  48. Sigal RJ, Kenny GP, Wasserman DH, et al.: Physical activity/exercise and type 2 diabetes. A consensus statement from the American Diabetes Association. Diabetes Care 2006, 29:1433–1438.

    Article  PubMed  Google Scholar 

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Correspondence to Glenn A. Gaesser PhD.

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Gaesser, G.A. Exercise for prevention and treatment of cardiovascular disease, type 2 diabetes, and metabolic syndrome. Curr Diab Rep 7, 14–19 (2007). https://doi.org/10.1007/s11892-007-0004-8

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