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Epidemiology
Protocol
Sequelae of multidrug-resistant tuberculosis: protocol for a systematic review and meta-analysis
  1. Kefyalew Addis Alene1,2,
  2. Archie C A Clements1,
  3. Emma S McBryde3,
  4. Ernesto Jaramillo4,
  5. Knut Lonnroth5,
  6. Debebe Shaweno6,
  7. Kerri Viney1,5
  1. 1 Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, Australia
  2. 2 Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
  3. 3 Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia
  4. 4 Global TB Programme, World Health Organization, Geneva, Switzerland
  5. 5 Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
  6. 6 Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
  1. Correspondence to Kefyalew Addis Alene; kefyalew.alene{at}anu.edu.au

Abstract

Introduction The sequelae of multidrug-resistant tuberculosis (MDR-TB) are poorly understood and inconsistently reported. We will aim to assess the existing evidence for the clinical, psychological, social and economic sequelae of MDR-TB and to assess the health-related quality of life in patients with MDR-TB.

Methods and analysis We will perform a systematic review and meta-analysis of published studies reporting sequelae of MDR-TB. We will search PubMed, SCOPUS, ProQuest, Web of Science and PsychINFO databases up to 5 September 2017. MDR-TB sequelae will include any clinical, psychological, social and economic effects as well as health-related quality of life that occur after MDR-TB treatment or illness. Two researchers will screen the titles and abstracts of all citations identified in our search, extract data, and assess the scientific quality using standardised formats. Providing there is appropriate comparability in the studies, we will use a random-effects meta-analysis model to produce pooled estimates of MDR-TB sequelae from the included studies. We will stratify the analyses based on treatment regimen, comorbidities (such as HIV status and diabetes mellitus), previous TB treatment history and study setting.

Ethics and dissemination As this study will be based on published data, ethical approval is not required. The final report will be disseminated through publication in a peer-reviewed scientific journal and will also be presented at relevant conferences.

PROSPERO registration number CRD42017073182.

  • multidrug-resistant tuberculosis
  • MDR-TB
  • sequelae
  • systematic review
  • meta-analysis
  • protocol

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2017-019593

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    Footnotes

    • Contributors KAA, KV and EJ conceived the study. KAA developed the search strategy and drafted the protocol. KV improved the drafted protocol. KL and EJ provided expertise to the section on psychosocial and economic burden of MDR-TB. ACAC, ESM, DS and KAA critically revised the manuscript for methodological and intellectual content. All authors have read and approved the final manuscript.

    • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Author note If there is a need to amend this protocol, the date of each amendment and the reason for the change will be described.