A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol

David Currow; Gareth John Watts; Miriam Johnson; Christine F McDonald; John O Miners; Andrew A Somogyi; Linda Denehy; Nicola McCaffrey; Danny J Eckert; Philip McCloud; Sandra Louw; Lawrence Lam; Aine Greene; Belinda Fazekas; Katherine C Clark; Kwun Fong; Meera R Agar; Rohit Joshi; Sharon Kilbreath; Diana Ferreira; Magnus Ekström

doi:10.1136/bmjopen-2017-018100

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A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol

Authors

David Currow Discipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK PubMed articles Google scholar articles
Gareth John Watts Department of Palliative Care, Calvary Mater Newcastle, Newcastle, Australia PubMed articles Google scholar articles
Miriam Johnson Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK Hull York Medical School, University of Hull, Hull, UK PubMed articles Google scholar articles
Christine F McDonald Department of Austin Health, Respiratory and Sleep Medicine, Austin Hospital, Heidelberg, Australia PubMed articles Google scholar articles
John O Miners Clinical Pharmacology School of Medicine, Flinders University, Adelaide, Australia PubMed articles Google scholar articles
Andrew A Somogyi Department of Clinical Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, Australia PubMed articles Google scholar articles
Linda Denehy School of Health Sciences, University of Melbourne, Parkville, Victoria, Australia PubMed articles Google scholar articles
Nicola McCaffrey Discipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia PubMed articles Google scholar articles
Danny J Eckert Neuroscience Research Australia (NeRA) Randwick, New South Wales, Australia PubMed articles Google scholar articles
Philip McCloud MCloud Consulting Group, Belrose, New South Wales, Australia PubMed articles Google scholar articles
Sandra Louw MCloud Consulting Group, Belrose, New South Wales, Australia PubMed articles Google scholar articles
Lawrence Lam Faculty of Health, University of Technology Sydney, Sydney, Australia PubMed articles Google scholar articles
Aine Greene Southern Adelaide Palliative Services, Adelaide, South Australia, Australia PubMed articles Google scholar articles
Belinda Fazekas Discipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia PubMed articles Google scholar articles
Katherine C Clark Department of Palliative Care, Calvary Mater Newcastle, Newcastle, Australia School of Medicine and Public Health, The University if Newcastle, Newcastle, New South Wales, Australia PubMed articles Google scholar articles
Kwun Fong Thoracic Research Centre, The Prince Charles Hospital School of Medicine, University of Queensland, Australia PubMed articles Google scholar articles
Meera R Agar Discipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia Faculty of Health, University of Technology Sydney, Sydney, Australia Clinical Trials, Ingham Institute of Applied Medical Research, Sydney, Australia South West Sydney Clinical School, University of New South Wales, Sydney, Australia PubMed articles Google scholar articles
Rohit Joshi Department of Medical Oncology, University of Adelaide Lyell MEwin Hospital, Adelaide, Australia PubMed articles Google scholar articles
Sharon Kilbreath Faculty of Health, University of Technology Sydney, Sydney, Australia PubMed articles Google scholar articles
Diana Ferreira Discipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia PubMed articles Google scholar articles
Magnus Ekström Discipline, Palliative and Supportive Services, Flinders University, Adelaide, Australia Department of Respiratory Medicine and Allergology, Institution for Clinical Sciences, Lund University, Sweden PubMed articles Google scholar articles
On behalf of the Australian national Palliative Care Clinical Studies Collaborative (PaCCSC)
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Correspondence to Professor David Currow; david.currow{at}sa.gov.au

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Currow D, Watts GJ, Johnson M On behalf of the Australian national Palliative Care Clinical Studies Collaborative (PaCCSC), et al

BMJ Open 2017;7:e018100. doi: 10.1136/bmjopen-2017-018100

Publication history

Received June 6, 2017
Accepted June 7, 2017
First published July 17, 2017.

Online issue publication

December 24, 2019

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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