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  • Transcatheter closure, mini-invasive closure and open-heart surgical repair for treatment of perimembranous ventricular septal defects in children: a protocol for a network meta-analysis

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Cardiovascular medicine
Protocol
Transcatheter closure, mini-invasive closure and open-heart surgical repair for treatment of perimembranous ventricular septal defects in children: a protocol for a network meta-analysis
  1. Tao You1,
  2. Kang Yi1,
  3. Zhao-hong Ding2,
  4. Xiao-dong Hou1,
  5. Xing-guang Liu1,
  6. Xin-kuan Wang1,
  7. Long Ge3,
  8. Jin-hui Tian3
  1. 1 Department of Cardiovascular Surgery, Gansu Provincial Hospital, Lanzhou, China
  2. 2 Department of Nursing, Gansu Provincial Hospital, Lanzhou, China
  3. 3 Evidence-Based Medicine Center, Lanzhou University, Lanzhou, China
  1. Correspondence to Dr Tao You; youtao2016{at}126.com

Abstract

Introduction Both transcatheter device closure and surgical repair are effective treatments with excellent midterm outcomes for perimembranous ventricular septal defects (pmVSDs) in children. The mini-invasive periventricular device occlusion technique has become prevalent in research and application, but evidence is limited for the assessment of transcatheter closure, mini-invasive closure and open-heart surgical repair. This study comprehensively compares the efficacy, safety and costs of transcatheter closure, mini-invasive closure and open-heart surgical repair for treatment of pmVSDs in children using Bayesian network meta-analysis.

Methods and analysis A systematic search will be performed using Chinese Biomedical Literature Database, China National Knowledge Infrastructure, PubMed, EMBASE.com and the Cochrane Central Register of Controlled Trials to include random controlled trials, prospective or retrospective cohort studies comparing the efficacy, safety and costs of transcatheter closure, mini-invasive closure and open-heart surgical repair. The risk of bias for the included prospective or retrospective cohort studies will be evaluated according to the risk of bias in non-randomised studies of interventions (ROBINS-I). For random controlled trials, we will use risk of bias tool from Cochrane Handbook version 5.1.0. A Bayesian network meta-analysis will be conducted using R-3.3.2 software.

Ethics and dissemination Ethical approval and patient consent are not required since this study is a network meta-analysis based on published trials. The results of this network meta-analysis will be submitted to a peer-reviewed journal for publication.

Protocol registration number CRD42016053352.

  • transcatheter closure
  • mini-invasive closure
  • open-heart surgical repair
  • perimembranous ventricular septal defects
  • children
  • protocol
  • network meta-analysis

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-015642

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    Footnotes

    • Contributors Conception and design of research (TY, KY, ZD, XH and JT); tested the feasibility of the study (TY, KY, XL and XW); wrote the manuscript (TY); approved the final manuscript (TY, LG and JT).

    • Competing interests None declared.

    • Patient consent Patient consent are not required since this is a meta-analysis based on published studies.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement None.