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Diabetes and endocrinology
Cohort profile
Prevalence, clinical features and risk assessment of pre-diabetes in Spain: the prospective Mollerussa cohort study
  1. María Belén Vilanova1,
  2. Mireia Falguera1,
  3. Josep Ramon Marsal2,3,4,5,
  4. Esther Rubinat6,7,8,
  5. Núria Alcubierre9,
  6. Esmeralda Catelblanco6,7,10,
  7. Minerva Granado-Casas6,
  8. Neus Miró11,
  9. Àngels Molló12,
  10. Manel Mata-Cases6,7,13,
  11. Josep Franch-Nadal6,7,14,
  12. Didac Mauricio6,7,10
  1. 1 Primary Health Care Centre Igualada Nord, Consorci Sanitari de l’Anoia, Servei Català de la Salut, Barcelona, Spain
  2. 2 Unitat de Suport a la Recerca, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Lleida, Spain
  3. 3 Epidemiology Unit of the Cardiovascular Service, Hospital Universitari Vall d'Hebron, Barcelona, Spain
  4. 4 CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Barcelona, Spain
  5. 5 Departament of Pediatrics, Obstetriccs and Ginaecoloy, and Preventive Mdicine, Autonomous University of Barcelona, Bellaterra, Spain
  6. 6 Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain
  7. 7 CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
  8. 8 Faculty of Nursing and Physiotherapy, University of Lleida, Lleida, Spain
  9. 9 Avantmèdic, & Centre Mèdic Pla d'Urgell, Mollerussa, Lleida, Spain
  10. 10 Department of Endocrinology and Nutrition, Health Sciences Research Institute & University Hospital Universitari Germans Trias i Pujol, Badalona, Spain
  11. 11 Primary Health Care Centre Tàrrega, Gerència d’Atenció Primaria, Institut Català de la Salut, Lleida, Spain
  12. 12 Primary Health Care Center Guissona, Gerència d’Atenció Primaria, Institut Català de la Salut, Lleida, Spain
  13. 13 Primary Health Care Center La Mina, Gerència d’Àmbit d’Atenció Primària Barcelona Ciutat, Institut Català de la Salut, Sant Adrià de Besòs, Spain
  14. 14 Primary Health Care Center Raval Sud, Gerència d’Atenció Primaria, Institut Català de la Salut, Barcelona, Spain
  1. Correspondence to Dr Didac Mauricio; didacmauricio{at}gmail.com

Abstract

Purpose The Mollerussa prospective cohort was created to study pre-diabetes in a population-based sample from the primary care setting in the semirural area of Pla d’Urgell in Catalonia (Spain). The aims of the study were to assess the prevalence of pre-diabetes in our population, the likelihood to develop overt diabetes over time and to identify risk factors associated with the progression of the condition.

Participants The cohort includes 594 subjects randomly selected between March 2011 and July 2014 from our primary care population, who were older than 25 years, consented to participate and did not have a recorded diagnosis of diabetes.

Findings to date At baseline, we performed a clinical interview to collect demographic, clinical and lifestyle (including a nutritional survey) characteristics; carotid ultrasound imaging to assess subclinical cardiovascular disease was also performed, and a blood sample was collected, with an overall <5% rate of missing data. An additional blood draw was performed 12 months after initial recruitment to reassess laboratory results in patients initially identified as having pre-diabetes, with an 89.6% retention rate. Several studies investigating various hypotheses are currently ongoing.

Future plans All subjects recruited during the cohort creation will be followed long-term through annual extraction of data from health records stored in the electronic Clinical station in Primary Care database. The Mollerussa cohort will thus be a sound population-based sample for multiple future research projects to generate insights into the epidemiology and natural history of pre-diabetes in Spain.

  • prediabetes
  • diabetes mellitus
  • primary health care
  • cohort study

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-015158

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    Footnotes

    • Contributors MF, JRM and DM conceived and designed the study; MBV, JF-N, and AM participated in the study design; MBV, MF, ER, NA, MG-C, NM and AM collected the data; EC built and managed the database; JRM managed the database, contributed to data cleaning, performed the statistical analyses and contributed to interpretation of the data; MBV, DM, JF-N and MM-C wrote the manuscript. All authors critically reviewed the manuscript and approved the final version to be published.

    • Funding This study was funded by Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol). The funding source had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; or preparation, review or approval of the manuscript.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Ethics Committee of the Primary Health Care University Research Institute (IDIAP) Jordi Gol (P12/043).

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement This article describes the establishment of a longitudinal cohort and early findings, and full results will be submitted for peer-reviewed publication in due course. The authors are willing to share unpublished data with interested parties upon request because they contain identifying human information and are unsuitable for public deposition. Requests may be made to the corresponding author (didacmauricio@gmail.com).

    • Correction notice This paper has been amended since it was published Online First. Owing to a scripting error, some of the publisher names in the references were replaced with 'BMJ Publishing Group'. This only affected the full text version, not the PDF. We have since corrected theseerrors and the correct publishers have been inserted into the references.

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