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Evidence based practice
Protocol
Interventions for preventing mother-to-child HIV transmission: protocol of an overview of systematic reviews
  1. Windy Mariane Virenia Wariki1,
  2. Erika Ota2,
  3. Rintaro Mori3,
  4. Charles S Wiysonge4,
  5. Hacsi Horvath5,
  6. Jennifer S Read5
  1. 1 Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia
  2. 2 Graduate School of Nursing Science, Global Health Nursing, St. Luke’s International University, Tokyo, Japan
  3. 3 Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan
  4. 4 Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa
  5. 5 Global Health Sciences, University of California San Francisco, San Francisco, California, USA
  1. Correspondence to Dr Windy Mariane Virenia Wariki; wwariki{at}gmail.com

Abstract

Introduction Various interventions to prevent mother-to-child-transmission (MTCT) of HIV have been investigated and implemented. A number of systematic reviews assessing the efficacy of interventions for the prevention of MTCT of HIV reported antiretroviral prophylaxis, caesarean section before labour and before ruptured membranes, and complete avoidance of breastfeeding were efficacious for preventing MTCT of HIV. Recent WHO guidelines recommend lifelong antiretroviral therapy for all pregnant women for treatment of the woman’s own HIV infection and for prevention of MTCT of HIV. Therefore, the objective of this overview is to evaluate the currently available systematic reviews of interventions for preventing MTCT of HIV, and to identify the current best evidence-based interventions for reducing the risk of MTCT of HIV.

Methods and analysis We will include only peer-reviewed systematic reviews of randomised or quasi-randomised controlled trials assessing the effects of interventions for preventing MTCT of HIV that target both HIV-infected women and children aged 2 years and younger born to HIV-infected women. We will search the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effectiveness, Ovid MEDLINE and EMBASE. We will assess review eligibility, the methodological quality of included systematic reviews using A Measurement Tool to Assess The Systematic Reviews and will extract data, comparing our results and resolving discrepancies by consensus. Finally, we will independently assess the certainty of the evidence using Grades of Recommendation, Assessment, Development and Evaluation.

Ethics and dissemination Ethics approval is not required. We will publish the results in a peer-reviewed journal and present at conferences, which will inform future research and will be useful for healthcare managers, administrators and policymakers to guide resource allocation decisions and optimisation of interventions to prevent the MTCT of HIV.

  • HIV
  • mother-to-child-transmission
  • prevention
  • systematic review

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-014332

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    Footnotes

    • Contributors WMVW, EO and RM designed, set up and drafted the protocol. JSR, CSW and HH revised and supervised development of the protocol and made several substantive edits and suggestions. All authors read and approved the final protocol.

    • Funding The Grant of National Center for Child Health and Development 26A-5, Japan; Japan Agency for Medical Research and Development, Japan AMED No.27300101; Scheme for Academic Mobility and Exchange (SAME) program of Directorate of Science, Technology, and Higher Education Resources, Ministry of Research, Technology, and Higher Education, Indonesia, 2015; Project for Baby and Infant in Research of healTH and Development to Adolescent and Young adult, Japan Agency for Medical Research and Development (17gk0110009h003)

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.