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  1. Antonia Johnston
  1. BMJ, London, UK
  1. Correspondence to Antonia Johnston; production.bmjopen{at}bmj.com

Abstract

Introduction: In the last decade, video-assisted thoracoscopic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC) has had a major effect on thoracic surgery. Retrospective series have reported benefits of VATS as compared to open thoracotomy in terms of postoperative pain, postoperative complications and length of hospital stay. However, no large randomized control trial has been conducted to assess the reality of the potential benefits of VATS lobectomy or its medico-economic impact. Methods and analysis: The French National Institute of Health funded Lungsco01 to determine whether VATS for lobectomy is superior to open thoracotomy for the treatment of NSCLC in terms of economic cost to society. This trial will also include an analysis of postoperative outcomes, the length of hospital stay, the quality of life, long-term survival and locoregional recurrence. The study design is a two-arm parallel randomized controlled trial comparing VATS lobectomy with lobectomy using thoracotomy for the treatment of NSCLC. Patients will be eligible if they have proven or suspected lung cancer which could be treated by lobectomy. Patients will be randomized via an independent service. All patients will be monitored according to standard thoracic surgical practices. All patients will be evaluated at day 1, day 30, month 3, month 6, month 12 and then every year for 2 years thereafter. The recruitment target is 600 patients. Ethics and dissemination: The protocol has been approved by the French National Research Ethics Committee (CPP Est I: 09/06/2015) and the French Medicines Agency (09/06/2015). Results will be presented at national and international meetings and conferences and published in peer-reviewed journals. Trial registration: Current control trial NCT02502318 available at https://clinicaltrials.gov/"

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Williams J, Hagger-Johnson G. Childhood academic ability in relation to cigarette, alcohol and cannabis use from adolescence into early adulthood: Longitudinal Study of Young People in England (LSYPE). BMJ Open 2017;7:e012989. doi: 10.1136/bmjopen-2016-012989

There are some errors in the RR and 95% CI values in the Results paragraph of the Abstract. This paragraph should read as follows:

Results

In multinomial logistic regression models adjusting for a range of covariates, the high (vs low) academic ability reduced the risk of persistent cigarette smoking (RR=0.62; CI 95% 0.48 to 0.81) in early adolescence. High (vs low) academic ability increased the risk of occasional (RR=1.25; CI 95% 1.04 to 1.51) and persistent (RR=1.83; CI 95% 1.50 to 2.23) regular alcohol drinking in early adolescence and persistent (RR=2.28; CI 95% 1.84 to 2.82) but not occasional regular alcohol drinking in late adolescence. High (vs low) academic ability was also positively associated with occasional (RR=1.50; CI 95% 1.22 to 1.83) and persistent (RR=1.91; CI 95% 1.57 to 2.34) cannabis use in late adolescence.

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