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Ophthalmology
Research
Vascular flow density in pathological myopia: an optical coherence tomography angiography study
  1. Jing Mo1,
  2. Anli Duan1,
  3. Szyyann Chan1,
  4. Xuefei Wang1,
  5. Wenbin Wei1,2
  1. 1Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
  2. 2Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing, China
  1. Correspondence to Professor Wenbin Wei; weiwenbintr{at}163.com

Abstract

Objectives To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography.

Design A prospective comparative study was conducted from December 2015 to March 2016.

Setting Participants were recruited in Beijing Tongren Hospital.

Participants A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0.50D to −0.50D), 41 eyes with high myopia (HM; MSE ≤−6.00D, without pathological changes), and 45 eyes with pathological myopia (PM; MSE ≤−6.00D and axial length (AL) ≥26.5 mm, and with pathological changes).

Main outcome measures Macular, choriocapillaris and radial peripapillary capillary (RPC) flow densities were measured and compared between groups, and their relationships with AL and best corrected visual acuity (BCVA) were analysed.

Results Significant differences were found in macular, choriocapillaris and RPC flow densities among the three groups (p<0.05). Multiple comparisons revealed that, compared with the EM and HM groups, macular and RPC flow densities of the PM group were significantly decreased (p<0.05), but no significant difference in choriocapillaris flow density was found between the PM and HM groups (p=0.731). Compared with the EM group, retinal flow density in the macular and arcuate fibre region was not decreased in the HM group. In addition, there was a negative correlation between AL and superficial macular flow density (β=−0.542, p<0.001), deep macular flow density (β=−0.282, p=0.002) and RPC flow density (β=−0.522, p<0.001); and a positive correlation between BCVA and superficial macular flow density (β=0.194, p=0.021), deep macular flow density (β=0.373, p<0.001), and choriocapillaris flow density (β=0.291, p=0.001).

Conclusions Macular and RPC flow densities decreased in pathological myopia compared with high myopia and emmetropia. No significant decrease of retinal flow density in the macular and arcuate fibre region was found in high myopic eyes compared with emmetropic eyes. Moreover, macular and RPC flow densities were negatively related to AL, and macular flow density was positively related to BCVA.

  • Pathologic Myopia
  • OCT Angiography
  • Vascular Flow Density

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-013571

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    Footnotes

    • Contributors WW and JM conceived of and designed the study. JM, AD and XW performed the study. JM and SC analysed the data. WW and JM wrote the manuscript.

    • Funding This work was supported by the Beijing Municipal Administration of Hospitals' Ascent Plan(code: DFL20150201); Science & Technology Project of Beijing Municipal Science & Technology Commission (code: Z151100001615052); National Natural Science Foundation of China (Nr.81570891); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (code: ZYLX201307); National Natural Science Foundation of China (Nr. 81272981); Beijing Natural Science Foundation (Nr. 7151003); Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau No. 2014-2-003.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval This study was approved by the Medical Ethics Committee of the Beijing Tongren Hospital.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement No additional data are available.