Article Text


Retrospective observational study of trends in hospital admissions for idiopathic pulmonary fibrosis in Spain (2004–2013) using administrative data
  1. Fernando Pedraza-Serrano1,
  2. Ana López de Andrés2,3,
  3. Rodrigo Jiménez-García2,3,
  4. Isabel Jiménez-Trujillo2,3,
  5. Valentín Hernández-Barrera2,3,
  6. Gema Sánchez-Muñoz1,
  7. Luis Puente-Maestu1,
  8. Javier de Miguel-Díez1
  1. 1Respiratory Department, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain
  2. 2Preventive Medicine and Public Health Teaching and Research Unit, Department of Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain
  3. 3Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain
  1. Correspondence to Dr Javier de Miguel Díez; javier.miguel{at}


Objective To assess changes in incidence, diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), economic costs and in-hospital mortality (IHM) associated with idiopathic pulmonary fibrosis (IPF).

Methods We identified patients hospitalised with IPF in Spain from 2004 to 2013. Data were collected from the National Hospital Discharge Database.

Results The study population comprised 22 214 patients. Overall crude incidence increased from 3.82 to 6.98 admissions per 100 000 inhabitants from 2004 to 2013 (p<0.05). The percentage of lung biopsies decreased significantly from 10.68% in 2004 to 9.04% in 2013 (p<0.05). The percentage of patients with a Charlson comorbidity index ≥2 was 15.14% in 2004, increasing to 26.95% in 2013 (p<0.05). IHM decreased from 14.77% in 2004 to 13.72% in 2013 (adjusted OR 0.98; 95% CI 0.97 to 0.99). Mean LOHS was 11.87±11.18 days in 2004, decreasing to 10.20±11.12 days in 2013 (p<0.05). The mean cost per patient increased from €4838.51 in 2004 to €5410.90 in 2013 (p<0.05).

Conclusions The frequency of hospital admissions for IPF increased during the study period, as did healthcare costs. However, IHM and LOHS decreased.

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  • Contributors JdM-D participated in the study concept, design, coordination, statistical analysis and drafting of the manuscript. FP-S, ALdA, RJ-G, IJ-T, VH-B, GS-M and LP-M participated in the study concept, design, statistical analysis and drafting of the manuscript. All authors have read and approved the final version.

  • Funding This study was partly funded by URJC-Banco Santander to the Grupo de Excelencia Investigadora ITPSE (grant number 30VCPIGI03).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Any investigator can apply for the databases filling the questionnaire available at All other relevant data are in the paper.

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