Responses

PDF

Risk of autism spectrum disorder in offspring following paternal use of selective serotonin reuptake inhibitors before conception: a population-based cohort study
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

PLEASE NOTE:

  • Responses are moderated before posting and publication is at the absolute discretion of BMJ, however they are not peer-reviewed
  • Once published, you will not have the right to remove or edit your response. Removal or editing of responses is at BMJ's absolute discretion
  • If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patient's written consent to publication and send them to the editorial office before submitting your response [Patient consent forms]
  • By submitting this response you are agreeing to our full [Response terms and requirements]
Publication Date - String

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    Thank you for your suggestion
    • Fen Yang, Clinical Epidemiology Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China Department of Clinical Epidemi

    Thank you for your suggestion. We agree with you that parental autistic disorders might increase the risk of ASD in children. In our study, we set all parental psychiatric disorders (ICD-10 codes F00-F99) including autism disorders (ICD-10 codes F84.0 F84.1, F84.5, F84.8 and F84.9) as potential confounding factors, and we adjusted for mother psychiatric disorders (including ASD) in model 1, and father psychiatric disorders (including ASD) in model 2. Besides, we also conducted sibling-matched analyses to control for shared family-related confounding factors like genetic liability for neuropsychiatric conditions.

    Conflict of Interest:
    None declared.
  • Published on:
    Have you considered parental autism as a confounding factor?
    • Lindsay Lee, Psychology Student, wife, parent & carer of autistics for over 30 years Anglia Ruskin University

    It does not appear that you have considered the possibility of the parents, especially the fathers, being autistic themselves, in this study. We know that around 70% of autistics suffer mental health problems so it would follow that a there is a high likelihood of an autistic parent (who may or may not have a diagnosis themselves) might be on SSRI or other depression medication prior to conception. I would see this as a highly significant potential confounding factor to this study.

    Conflict of Interest:
    None declared.