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  • Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol

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Epidemiology
Protocol
Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol
  1. Gillian M Maher1,2,
  2. Gerard W O’Keeffe1,3,
  3. Louise C Kenny1,4,
  4. Patricia M Kearney2,
  5. Ted G Dinan5,6,
  6. Ali S Khashan1,2
  1. 1 The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital and University College Cork, Cork, Ireland
  2. 2 Department of Epidemiology and Public Health, Western Gateway Building, University College Cork, Cork, Ireland
  3. 3 Department of Anatomy and Neuroscience, Western Gateway Building, University College Cork, Cork, Ireland
  4. 4 Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, University College Cork, Cork, Ireland
  5. 5 Department of Psychiatry, Cork University Hospital and University College Cork, Cork, Ireland
  6. 6 APC Microbiome Institute, University College Cork, Cork, Ireland
  1. Correspondence to and Dr Ali S Khashan; a.khashan{at}ucc.ie

Abstract

Introduction Hypertensive disorders of pregnancy (HDPs), that is chronic hypertension, gestational hypertension, pre-eclampsia (de novo or superimposed on chronic hypertension) and white coat hypertension, affect approximately 5%–15% of pregnancies. HDP exposure has been linked to an increased risk of autism spectrum disorder, attention deficit/hyperactivity disorder and other neurodevelopmental disorders in children. However, findings are inconsistent, and a clear consensus on the impact of HDPs on the risk of neurodevelopmental disorders is needed. Therefore, we aim to synthesise the published literature on the relationship between HDPs and the risk of neurodevelopmental disorders in the form of a systematic review and meta-analysis.

Methods and analysis We will include cohort, case–control and cross-sectional studies in which diagnosis of an HDP was reported, and neurodevelopmental disorders were the outcome of interest based on a preprepared protocol. A systematic search of PubMed, CINAHL, Embase, PsycINFO and Web of Science will be conducted in accordance with a detailed search strategy. Two authors will independently review the titles and abstracts of all studies, perform data extraction using a standardised data collection form and assess study quality using a bias classification tool. Meta-analyses will be performed to calculate overall pooled estimates using the generic inverse variance method. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses.

Ethics and dissemination This proposed systematic review and meta-analysis is based on published data, therefore, does not require ethics approval. Findings will be presented at scientific conferences and disseminated through publication in a peer-reviewed journal.

Registration CRD42017068258.

  • pre-eclampsia
  • gestational hypertension
  • neurodevelopment
  • epidemiology

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2017-018313

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    Footnotes

    • Contributors GMM and ASK conceived and designed the protocol, and GMM drafted the protocol manuscript. GMM and ASK participated in the development of the search strategy. GMM and GWOK planned the data extraction. GMM and PMK planned quality appraisal of included studies. GWOK, LCK, PMK, TGD and ASK critically revised the manuscript for methodological and intellectual content. All authors approved the final version.

    • Funding This publication has emanated from research conducted with the financial support of the Health Research Board (HRB), Ireland under the SPHeRE (Structured Population andHealth-services Research Education) Programme and from Science Foundation Ireland (SFI) in the form of a research centre grant to the Irish Centre For Fetal and Neonatal Translational Research under the grant number INFANT-12/RC/2272. The Alimentary Pharmabiotic Centre (APC) is a research centre also funded by SFI under the grant number SFI/12/RC/2273.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.