Article Text


Burn injury and long-term nervous system morbidity: a population-based cohort study
  1. Thirthar P Vetrichevvel1,
  2. Sean M Randall2,
  3. Mark W Fear1,
  4. Fiona M Wood1,3,
  5. James H Boyd2,
  6. Janine M Duke1
  1. 1Burn Injury Research Unit, School of Surgery, University of Western Australia, Perth, Western Australia, Australia
  2. 2Centre for Data Linkage, Curtin University, Perth, Western Australia, Australia
  3. 3Burns Service of Western Australia, Fiona Stanley Hospital and Princess Margaret Hospital, Perth, Western Australia, Australia
  1. Correspondence to Professor Janine M Duke; janine.duke{at}


Objective To investigate if children and adults who are hospitalised for a burn injury have increased long-term hospital use for nervous system diseases.

Design A population-based retrospective cohort study using linked administrative health data from the Western Australian Data Linkage System.

Participants Records of 30 997 persons hospitalised for a first burn injury in Western Australia during the period 1980–2012, and 123 399 persons who were age and gender frequency matched with no injury admissions randomly selected from Western Australia's birth registrations and electoral roll.

Main outcome measures Admission rates and summed length of stay for nervous system diseases. Negative binomial and Cox proportional hazards regression modelling were used to generate incidence rate ratios (IRRs) and HRs with 95% CIs, respectively.

Results After adjustment for demographic factors and pre-existing health status, the burn injury cohort had 2.20 times (95% CI 1.86 to 2.61) as many nervous system admissions and 3.25 times the number of days in hospital (95% CI: 2.28 to 4.64) than the uninjured cohort. This increase was found for those who had sustained burns during childhood (<15 years: IRR, 95% CI: 1.97, 1.49 to 2.61) and early to mid-adulthood (15–45 years: IRR, 95% CI: 2.70, 2.06 to 3.55) and older adults (≥45 years: IRR, 95% CI: 1.62, 1.33 to 1.97). Significantly elevated first-time postburn admissions were observed for children for 15 years postburn discharge (0–5 years: HR, 95% CI: 1.97, 1.75 to 2.22; 5–15 years: HR, 95% CI: 1.44, 1.28 to 1.63) and for adults 45 years and older at index burn for 5 years postburn only (HR, 95% CI: 1.72, 1.42 to 2.09).

Conclusions Burn injury appears to be associated with increased nervous system-related morbidity for many years after burn injury. Further work into the mechanisms and possible treatments to reduce this morbidity are warranted in light of these findings.

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Strengths and limitations of this study

  • Contributes valuable information on long-term effects of minor and severe burns on the nervous system.

  • Population-based cohort study using linked administrative data minimises issues of selection and reporting bias, and loss to follow-up.

  • The retrospective longitudinal study design included a comparison group.

  • Lack of individual-based risk factor data.


Long-term neuronal damage postburn injury is being increasingly identified. Systemic alterations in nerve fibre density,1 elevated levels of substance P positive nerve fibres (associated with pain and itch) in burn grafts,2 rapid and prolonged activation of microglial cells in the spinal cord,3 apoptosis in ventral horn motor neurons of the spinal cord4 and increased brain tissue levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-65 have all been identified postburn injury. However, the clinical implications of these changes for postburn morbidity remain unclear.

Sensory abnormalities in postburn scar have been studied extensively. Severe sensory deficit in touch, pressure and temperature sensation changes varying between 5% and 52% depending on the modality and depth of burn injury has been reported.6 Paraesthetic sensations including itching, warmth and coldness have been reported in different studies to be experienced by 10– 87% of patients.6 ,7 Chronic persistent pain after severe burn injury was reported by 52% of survey respondents, of which 55% reported interference with daily activities.8 The development of chronic pain is perceived to have a role of central and peripheral neuronal mechanisms.9 Electrodiagnostic studies using electromyography and motor nerve conduction velocities are more reflective of the physiology of the nerve and have shown features of polyneuropathy/mononeuropathy in 15–68% of patients after burn injury,10–13 while clinical abnormalities have been reported in ∼10% of patients and related to the average burn surface area and aetiology of burn injury.14 ,15

Studies of the central nervous system (CNS) involvement in burn injuries have been restricted to effects in the acute stage.16 ,17 There is also a dearth of studies identifying the effect of burn injury on pre-existing nervous system disorders in burn injury patients. In this study, population-based linked health administrative data were used to investigate if burn patients experienced increased longer term nervous system morbidity expressed in terms of hospital service use, when compared with an age-matched and gender frequency-matched cohort of individuals with no record of an injury admission.


This study used data from the Western Australian Population-based Burn Injury Project (WAPBIP), a population-based retrospective cohort study established in 2014 using linked health records. The data were provided from the Western Australian Data Linkage System that links administrative health data routinely for the whole population of Western Australia;18 regular quality assessments of the data and links are undertaken.19 The project was approved by the Human Research Ethics Committees of the University of Western Australia and the Western Australian Department of Health. The WAPBIP project supports multiple studies and project methods have been previously published.20–22

A de-identified extraction of all linked hospital morbidity records form the Hospital Morbidity Data System for all persons admitted to the hospital with an index burn injury in Western Australia, for the period from 1 January 1980 to 30 June 2012. The index burn injury was defined as the first hospital admission with a burn injury as the principal and/or additional diagnosis using the International Classification of Diseases (ICD) codes V.9 (ICD9-CM) 940-949 and V.10 (ICD10-AM) T20-T31. A population-based comparison cohort was randomly selected from the Western Australian birth registrations and electoral roll; any person with an injury hospitalisation during the study period was excluded from the non-injury cohort. The resultant uninjured comparison cohort was frequency matched on birth year (4:1) and gender of the burn injury cases for each year from 1980 to 2012.

Hospital and death data were linked to each cohort (burn, non-injury) for the period 1980–2012. Hospital admissions data included principal and additional diagnoses, age and gender, indigenous status, admission and discharge dates, burn injury characteristics (total body surface area per cent (TBSA%), depth and site) and residential postcode. TBSA% was classified as minor (TBSA<20%), severe (TBSA≥20%) and unspecified TBSA%. Indices of social disadvantage (least to most disadvantaged)23 and residential remoteness (major cities, inner regional, outer regional, remote and very remote)24 derived from the national census data were supplied for both cohorts. A variable to identify baseline comorbidity (yes/no) was generated using the Charlson comorbidity index25 with principal and additional diagnosis hospital data and a 5-year look back period.26 Mortality data included the date and cause of death. Admissions for diseases of the nervous system were identified using principal diagnosis data and defined by codes within ICD Chapter 6 (ICD10: G00-G99); ICD9 codes were mapped to ICD10 codes.27

The total number of years a person was at risk (person-years) was estimated from the final discharge date for the burn cases and this date was used for the respective frequency-matched non-injury controls. Categorical and non-parametric continuous variables were compared using χ2 and Kruskal-Wallis tests, respectively, with a statistical significance level of 5%.

The number of postburn admissions and summed length of stay for combined (G00-G99) and selected subgroups of nervous system diseases (G40-G47: episodic and paroxysmal disorders; G50-G59: nerve, nerve root and plexus disorders; and G60-G64: polyneuropathies and other peripheral nervous system disorders) were used as outcome measures. The admission of the index burn was not included in these outcomes. Crude yearly admission rates were calculated for these variables. Adjusted rate ratios were calculated using negative binomial regression. Sociodemographic (gender, indigenous, 5-year age group, social disadvantage, remoteness), year of admission (to adjust for temporal changes in treatments and referral patterns) and health status variables (baseline comorbidity, previous nervous system disease admission) were included as covariates in the models. Analyses were undertaken on the total burn and uninjured cohorts and subcohorts defined by gender and age at study start (<15, 15–45 and ≥45 years).

Cox proportional hazards models were used to assess admission rates for first-time hospital use for nervous system diseases after burn discharge and models were adjusted for demographic and health covariates. Analyses were performed on the cohorts excluding those with a previous admission for a nervous system condition, and also excluding those in the burn cohort with a record of a non-burn injury admission to avoid potential confounding from non-burn injury-related systemic effects.28 The proportional hazard assumption for the burn injured versus non-injured was tested29 and if preliminary results showed non-proportionality, adjusted HRs were modelled for time periods guided by Aalen's linear hazard models and graphs.30

Attributable risk percentages (AR%) were calculated as the adjusted rate ratio (HR) minus one, divided by the adjusted rate ratio (HR), multiplied by 100.31 AR% was used to estimate the proportion of incident admissions for diseases of the nervous system where burn injury was a component cause.32 ,33 Statistical analyses were performed using Stata V.12 (StataCorp. LP, College Station, Texas, USA).


Cohort characteristics

The burn cohort comprised 30 997 individuals hospitalised with a first burn injury and the uninjured cohort comprised 123 399 individuals age and gender frequency matched to burn cases. Over the 33-year study period, the burn and uninjured cohorts contributed a total of 485 707 and 2 009 370 person-years of observation, respectively, with median years of follow-up (IQR) by age group for burn versus non-injured: younger than 15 years, 18.1 (10.3–25.6) vs 17.9 (10.2–25.5); 15–45 years, 16.7 (8.4–25.0) vs 16.7 (8.8–25.0); 45 years and older, 9.0 (3.0–16.0) vs 13.0 (6.0–23.0).

The percentage of men in the burn (n=21 223) and the non-injured (n=82 875) cohort was 68% and the median age for both cohorts was 23 years with IQR 7–39 years. Refer to table 1 for a summary of sociodemographic and health status characteristics. The burn cohort had significantly higher proportions of those who were of indigenous status, from regional and remote areas, people who were socially disadvantaged, had pre-existing comorbidity and prior admission for nervous system disorders, when compared with the non-injury cohort. A third of the burn cohort (n=10 351) had a record of non-burn injury admission over the study period (preindex or postindex burn). Examination of length of hospital stay (median, IQR days) for the first burn admission suggested the high likelihood that those with unspecified TBSA (3, 1–10) were misclassified 0–10% TBSA burns (0–10% TBSA: 3, 1–9; 10–20% TBSA: 11, 4–19; 20–50% TBSA: 22, 11–39; 50–100% TBSA: 72, 38–118).

Table 1

Demographic and health characteristics of the burn and non-injury cohorts

Admission rates and length of stay

There were a total of 6121 hospital admissions occurring after burn discharge with a primary diagnosis of a nervous system disease. Overall, 7.3% of the burn cohort had a postburn nervous system admission (6.4% had 3 or less admissions; 0.4% >10 admissions). The number (%) of admissions by specific subconditions is shown in table 2. Admissions for episodic and paroxysmal disorders accounted for almost two-thirds of total postburn nervous system admissions.

Table 2

Number of postburn discharge admissions (%) for NS subconditions for the burn and non-injury cohorts

A total of 38 159 days were spent in hospital with a nervous system condition after hospitalisation for burns. For the burn cohort, the median length of hospital stay for nervous system conditions was 1 day (IQR 1–3) and for the uninjured cohort, 1 day (IQR 1–2).

Unadjusted rates of admissions and summed length of stay are shown in figure 1; rates of nervous system admissions and time spent in hospital with nervous system conditions were higher for those who had a burn injury when compared with uninjured controls.

Figure 1

Unadjusted rates of hospital admissions and cumulative LOS (per 100 PYs) for nervous system conditions comparing those with burn injury (combined severity) versus no injury. LOS, length of stay; PY, person-year.

After adjusting for demographic-based characteristics along with pre-existing health status, those hospitalised for a burn injury had over twice as many hospital admissions for a nervous system condition (IRR, 95% CI: 2.20, 1.86 to 2.61), and spent over three times as long in hospital (IRR, 95% CI: 3.25, 2.28 to 4.64). Subcohort analyses by decade of admission, adjusting for follow-up time, identified increased nervous system admissions for the burn cohort for each time period: 1980–1989 (IRR, 95% CI: 2.53, 1.90 to 3.35); 1990–1999 (IRR, 95% CI: 2.28, 1.72 to 3.01); 2000–2012: (IRR, 95% CI: 1.60, 1.27 to 2.00). This increase was found for those younger than 15 years (IRR, 95% CI: 1.97, 1.49 to 2.61), 15–45 years (IRR, 95% CI: 2.70, 2.06 to 3.55) and for those 45 years and older (IRR, 95% CI: 1.62, 1.33 to 1.97) at the time of burn injury. The increase was consistent when looking at gender-specific analyses (men—IRR, 95% CI: 2.26, 1.81 to 2.83; women—IRR, 95% CI: 2.17, 1.76 to 2.67).

Unadjusted rates of admissions for specific nervous system subcategories are shown in figure 2. After controlling for demographic factors and pre-existing health status, the burn cohort had a higher rate of admissions for episodic and paroxysmal disorders (IRR, 95% CI: 2.15, 1.77 to 2.60) and nerve, nerve root and plexus disorders (IRR, 95% CI: 1.23, 1.01 to 1.49). There was no difference in the rate of admissions between the burn and uninjured cohorts for polyneuropathies and other disorders of the peripheral nervous system (IRR, 95% CI: 1.26, 0.44 to 3.60). A significantly longer time was spent in hospital with episodic and paroxysmal disorders (IRR, 95% CI: 2.83, 1.96 to 4.10); nerve, nerve root and plexus disorders (IRR, 95% CI: 3.69, 2.17 to 6.28); and polyneuropathies and other disorders of the peripheral nervous system (IRR, 95% CI: 17.30, 5.32 to 56.25). Analysis by TBSA classification (table 3) shows increased admission rates occurring for those with severe, minor and unspecified TBSA burns.

Table 3

Adjusted IRRs and 95% CIs for recurrent admissions for NS subconditions, by burn severity versus no injury

Figure 2

Unadjusted rates (per 100 PYs) of hospital admissions for nervous system subconditions among those with burn injury (combined severity) versus no injury. PY, person-year.

Adjusted analyses excluding those in the burn cohort with burns of unspecified depth and erythema-only (first-degree) burns also showed increased postburn nervous system admissions (IRR, 95% CI: 1.96, 1.64 to 2.34).

Incidence—survival analysis

Survival analysis until first nervous system admission was performed on the cohorts excluding those with a previous admission for a nervous system condition, and also excluding those in the burn cohort with a record of a non-burn injury admission. The burn cohort comprised 19 741 members and 931 incident nervous system admissions were identified. The uninjured cohort comprised 121 925 individuals and 4224 incident nervous system admissions were identified.

Adjusted Cox regression analyses showed significantly elevated incident admission rates for the first 15 years after burn discharge, with higher rates observed for the first 5 years. Refer to table 4 for summary results of multivariate Cox regression analyses. Significant results were observed for 15 years postburn for male and female members of the burn cohort, as well as those younger than 45 years at the time of their burn admission. For adults 45 years and older, significantly elevated incident admission rates were observed for the first 5 years only. Those with minor burns and burns of unknown TBSA had significantly increased admission rates for 15 years postburn. The elevated admission rates for severe burns for the first 5 years postburn did not reach statistical significance.

Table 4

Adjusted HRs and 95% CIs for incident admissions for nervous system diseases (combined) after burn discharge, burn compared with uninjured cohort

The burn cohort (total) had a significantly higher rate of first-time admissions over the first 15 years after discharge for episodic and paroxysmal disorders (HR, 95% CI: 0–5 years: 2.00, 1.69 to 2.36; 5–15 years: 1.58, 1.33 to 1.88) and for nerve, nerve root and plexus disorders (HR, 95% CI: 0–5 years: 1.73, 1.38 to 2.16; 5–15 years: 1.34, 1.09 to 1.64). However, the elevated rate for incident admissions for polyneuropathies and other disorders of the peripheral nervous system (HR, 95% CI: 1.57, 0.92 to 2.67) did not reach statistical significance. In total, 290 first-time admissions for a nervous system disorder were attributable to burn injury.


This paper provides a comprehensive population-based assessment of hospital admissions for nervous system conditions experienced by burn patients after discharge for their initial burn injury. While hospital admissions data represent the more serious presentations of morbidity, the study found that after adjustment for sociodemographic and health factors, people with a burn injury sufficiently serious to require hospitalisation experienced twice the admissions (combined incident and prevalent) and spent three times longer in hospital for nervous system conditions, when compared with people with no record of an injury admission. Survival analyses have shown significantly elevated incident or first-time admissions for nervous system conditions for the first 5 years postburn, with those younger than 45 years of age at the time of burn experiencing elevated rate of first-time admissions for a period of 15 years after burn discharge. Admissions for episodic and paroxysmal disorders were the most common, representing 62% of admissions, followed by 15% of admissions for disorders of the nerve, the nerve root and plexus and 6% for polyneuropathies and peripheral disorders.

Severe burns have been shown to cause cerebral changes34 with CNS involvement demonstrated following acute peripheral insults to the body such as sepsis, surgery and organ injury.35 CNS inflammatory responses have also been demonstrated subsequent to severe burns (≥TBSA20%).36 ,37 Recent animal38 ,39 and in vitro research40 have shown that cytokines can directly induce dysfunction of the blood–brain barrier that can lead to burn injury-induced neuroinflammatory changes and neuron damage.34 The systemic inflammation triggered by severe burn injury and persistence of hypercortisolic state for up to 3 years after injury41 has been postulated to lead to loss of cytoprotective mechanisms and cognitive decline42 and could be a common aetiology for the observed changes in the central and peripheral nervous system. Superficial burns, although involving only the epidermis, initiate a significant inflammatory response and neuronal signalling (as evidenced by the accompanying substantial pain). Currently, the mediators that cause increased neurological disorders after burns are unknown; however, there is the potential for inflammatory and/or neuronal-mediated mechanisms to stimulate changes to peripheral nerves, even after superficial injury.

The group of admissions for episodic and paroxysmal disorders comprised admissions for seizures, migraine and other headache symptoms, sleep disorders and transient ischaemic attacks. The high number of postburn admissions for epilepsy and recurrent seizures was an interesting finding. While it is difficult to ascertain from the health administrative data if a burn was secondary to an epileptic seizure, the results showed a persistence of nervous system effects after discharge. However, decompensation of epilepsy had been noted in the acute injury phase after a burn. Decreased protein binding of phenytoin, resulting in enhanced excretion, coupled with hypermetabolism has been proposed as a causative factor.43 Although the case report by Gragnani and colleagues depicts acute decompensation after burn injury, long-term effects of burn injury on epilepsy/seizure disorders observed in our study could be explained by the hypermetabolic and inflammatory response persisting for up to 3 years after severe burn injury.41 Urinary epinephrine, norepinephrine, cortisol, serum cortisol, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon gamma (IFN-γ), TNF-α,IL-1b, IL-2, IL-5, IL-7, IL-10 and IL-17 were all found to be elevated in this study and cortisol, 11-deoxy cortisol and dehydroepiandrosterone sulfate have all been shown to be proconvulsant in animal models.44 Many other factors may also be important, including altered liver and kidney function and/or increased postburn use of antidepressants that can increase seizure risk.41 ,45–47 The data here strongly support further investigation into the cause of this increased incidence of seizure admissions postburn.

The elevated admission rate observed for polyneuropathies and other peripheral nervous system disorders experienced by the burn cohort did not reach statistical significance. Peripheral neuropathy in burn patients has been observed to be between 2% and 82%,12 ,48 ,49 with mononeuropathies/mononeuritis being identified as the most common presentation.14 Polyneuropathy has been described to be more common in full-thickness burns, where the TBSA>15% and when the initial length of stay is more than 20 days, suggesting polyneuropathy is predominantly a result of more severe injuries.13 ,15 In this study, we found a marginal increase in admissions for mononeuropathies (other mononeuropathies). Admissions for polyneuropathies were less common and may be related to the fact that a large proportion of the patients had minor burns (48%).

A clear burn severity ‘dose–response’ was not observed. This may in part be due to the small number of those with severe burns in this patient population and/or a ‘healthy’ survivor effect. An additional possibility is that survivors of severe burns received prolonged postburn care that resulted in earlier diagnoses and management of secondary pathologies, and reduced postburn admissions.

Strengths and limitations

This large population-based study of linked hospital and death records with long follow-up and a comparison to an uninjured cohort has provided comparative data on the long-term health effects on the nervous system experienced by those with burns. Such data are currently absent from the published literature. The results were adjusted for sociodemographic and pre-existing health status. The social disadvantage variable included in the models has demonstrated high correlation with lifestyle risk factors (including alcohol, smoking, substance abuse, diet and activity).50 Hospital data characteristically represent the more serious of diseases requiring admission for assessment and/or management, and the results of this study may under-represent conditions experienced by burn patients that are managed successfully by primary care. Future work that includes a non-burn trauma cohort will assist in the understanding and identification of burn injury-specific mechanisms. Linkage of pharmaceutical and or primary care data with hospital morbidity data would strengthen our ability to identify patients at greatest risk of secondary pathologies of the nervous system and optimal treatment pathways to mitigate such effects. The results of this study would be applicable to other countries of comparable demographic structure and healthcare systems.


After adjustment for sociodemographic and health status variables, when compared with a population-based random sample of people with no record of injury admission, those with a record of burn injury requiring hospitalisation, experienced significantly increased long-term nervous system morbidity, in terms of hospital admissions and length of stay. Our findings of increased hospital service use for CNS and peripheral nervous system morbidities support further investigation into the causes underlying this morbidity and possible strategies to ameliorate these long-term health problems.


The authors thank the staff of the Health Information Linkage Branch for access to the Western Australian Data Linkage System and for their assistance in obtaining the data, the WA Health Data Custodians for access to the core health datasets and the Western Australian Department of Health. The project was supported by the Raine Medical Research Foundation (Priming grant JMD). JMD is supported by Woodside Corporation. MWF is supported by Chevron Australia.


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  • Contributors All authors have made contributions to the paper and have authorised the submission. TPV contributed clinical interpretation of results and drafted the manuscript. JMD designed the study, supported data analyses and interpretation and supported manuscript preparation. SMR and JHB provided data management, analyses and data interpretation. MWF, SMR and FMW contributed clinical interpretation. All authors contributed to manuscript preparation and critical revision.

  • Funding Project data costs were supported by a Raine Medical Research Foundation Priming grant and Woodside corporate sponsorship via the Fiona Wood Foundation.

  • Competing interests None declared.

  • Ethics approval This study has received ethics approval from the University of Western Australia and the Western Australian Department of Health. Being a large population cohort study using de-identified linked data, approval included a waiver of informed consent.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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