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Following young people with perinatal HIV infection from adolescence into adulthood: the protocol for PHACS AMP Up, a prospective cohort study
  1. Katherine Tassiopoulos1,
  2. Kunjal Patel1,
  3. Julie Alperen1,
  4. Deborah Kacanek2,
  5. Angela Ellis3,
  6. Claire Berman1,
  7. Susannah M Allison4,
  8. Rohan Hazra5,
  9. Emily Barr6,
  10. Krystal Cantos1,
  11. Suzanne Siminski3,
  12. Michael Massagli1,
  13. Jose Bauermeister7,
  14. Danish Q Siddiqui8,
  15. Ana Puga9,
  16. Russell Van Dyke8,
  17. George R Seage III1
  18. for the Pediatric HIV/AIDS Cohort Study
  1. 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  2. 2Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  3. 3Frontier Science and Technology Research Foundation, Inc, Amherst, New York, USA
  4. 4Division of AIDS Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
  5. 5Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
  6. 6Department of Pediatric Infectious Diseases, University of Colorado, Children's Hospital Colorado, Aurora, Colorado, USA
  7. 7Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
  8. 8Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA
  9. 9Children's Diagnostic & Treatment Center, Inc., Fort Lauderdale, Florida, USA
  1. Correspondence to Dr Katherine Tassiopoulos; ktassiop{at}hsph.harvard.edu

Abstract

Introduction The first generation of adolescents born with HIV infection has reached young adulthood due to advances in treatment. It is important to continue follow-up of these individuals to assess their long-term medical, behavioural and mental health and ability to successfully transition to adulthood while coping with a chronic, potentially stigmatising condition. To accomplish this, and to maintain their interest in long-term research participation, we need to accommodate the changing lifestyles and interests of young adult study participants while ensuring valid data collection. We report the protocol for Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) Up, a prospective cohort study enrolling young adult participants for long-term follow-up.

Methods and analysis AMP Up is recruiting 850 young men and women 18 years of age and older—600 perinatally HIV-infected and a comparison group of 250 perinatally HIV-exposed, uninfected—at 14 clinical research sites in the USA and Puerto Rico. Recruitment began in April 2014 and is ongoing, with 305 participants currently enrolled. Planned follow-up is ≥6 years. Data are collected with a flexible hybrid of online and in-person methods. Outcomes include: transition to adult clinical care and retention in care; end-organ diseases; malignancies; metabolic complications; sexually transmitted infections; reproductive health; mental health and neurocognitive functioning; adherence to antiretroviral treatment; sexual behaviour and substance use; hearing and language impairments; and employment and educational achievement.

Ethics and dissemination The study received ethical approval from the Harvard T.H. Chan School of Public Health's institutional review board (IRB), and from the IRBs of each clinical research site. All participants provide written informed consent; for cognitively impaired individuals with legally authorised representatives, legal guardian permission and participant assent is obtained. Findings will be disseminated through peer-reviewed journals, conference presentations and participant summaries.

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