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Paediatrics
Protocol
PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research
  1. Mufiza Z Kapadia1,
  2. Lisa Askie2,
  3. Lisa Hartling3,
  4. Despina Contopoulos-Ioannidis4,
  5. Zulfiqar A Bhutta1,
  6. Roger Soll5,
  7. David Moher6,
  8. Martin Offringa1
  1. 1Department of Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
  2. 2Systematic Reviews & Health Technology Assessment, NHMRC Clinical Trials Centre, the University of Sydney, Sydney, New South Wales, Australia
  3. 3Department of Pediatrics, Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Alberta, Canada
  4. 4Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, and Meta Research Innovation Center at Stanford (METRICS), Stanford, California, USA
  5. 5Department of Pediatrics, University of Vermont College of Medicine; Vermont Oxford Network, Burlington, Vermont, USA
  6. 6Centres for Practice-Changing Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
  1. Correspondence to Dr Mufiza Z Kapadia; Mufiza.farid{at}gmail.com

Abstract

Introduction Paediatric systematic reviews differ from adult systematic reviews in several key aspects such as considerations of child tailored interventions, justifiable comparators, valid outcomes and child sensitive search strategies. Available guidelines, including PRISMA-P (2015) and PRISMA (2009), do not cover all the complexities associated with reporting systematic reviews in the paediatric population. Using a collaborative, multidisciplinary structure, we aim to develop evidence-based and consensus-based PRISMA-P-C (Protocol for Children) and PRISMA-C (Children) Extensions to guide paediatric systematic review protocol and completed review reporting.

Methods and analysis This project's methodology follows published recommendations for developing reporting guidelines and involves the following six phases; (1) establishment of a steering committee representing key stakeholder groups; (2) a scoping review to identify potential Extension items; (3) three types of consensus activities including meetings of the steering committee to achieve high-level decisions on the content and methodology of the Extensions, a survey of key stakeholders to generate a list of possible items to include in the Extensions and a formal consensus meeting to select the reporting items to add to, or modify for, the Extension; (4) the preliminary checklist items generated in phase III will be evaluated against the existing evidence and reporting practices in paediatric systematic reviews; (5) extension statements and explanation and elaboration documents will provide detailed advice for each item and examples of good reporting; (6) development and implementation of effective knowledge translation of the extension checklist, and an evaluation of the Extensions by key stakeholders.

Ethics and Dissemination This protocol was considered a quality improvement project by the Hospital for Sick Children's Ethics Committee and did not require ethical review. The resultant checklists, jointly developed with all relevant stakeholders, will be disseminated through peer-reviewed journals as well as national and international conference presentations. Endorsement of the checklist will be sought simultaneously in multiple journals.

  • systematic review
  • reporting guideline
  • pediatric

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2015-010270

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