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A very nice study with focused vision for future. Read it and appreciate with acknowledgement to bring this entire study to us. Would like to highlight a follow up of the said subjects as per their genetic makeup in this era of personalised medicine. Hypoxia and level of venous hypoxia as a key factor is missing to be aligned with calories intake and other factors which will define change the entire scope of study beside its implementation. The genes associated with obesity and involved in energy hemostasis must be considered at least as per study performed.