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Diabetes and endocrinology
Research
Association between serum soluble corin and hyperglycaemia: a cross-sectional study among Chinese adults
  1. Yan Liu1,2,
  2. Hao Peng1,2,
  3. Qiu Zhang1,2,3,
  4. Peipei Zhang1,2,
  5. Yunfan Tian1,2,
  6. Xiangqin Chao3,
  7. Yonghong Zhang1,2
  1. 1Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China
  2. 2Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China
  3. 3Center for Disease Prevention and Control of Gusu District, Suzhou, China
  1. Correspondence to Dr Yonghong Zhang; yhzhang{at}suda.edu.cn

Abstract

Objectives Decreased natriuretic peptides are risk factors for diabetes. As a physiological activator of natriuretic peptides, corin may play a role in glucose metabolism. Here, we aimed to test the hypothesis in a general population of China.

Design Cross-sectional study.

Setting A population study in Suzhou, China.

Participants A total of 2498 participants aged above 30 years were included in the study.

Outcome measures The association between serum soluble corin and hyperglycaemia was examined in men and women, using non-conditional logistic regression models, respectively.

Results Serum soluble corin, in men and women, was significantly higher in participants with hyperglycaemia than in those without (all p<0.001). OR of hyperglycaemia positively and significantly increased with serum soluble corin quartiles, in men (p for trend <0.001) and in women (p for trend=0.050), even after multivariate adjustment. Participants with a serum soluble corin, in men (OR=1.66, 95% CI 1.24 to 2.23) and women (OR=1.27, 95% CI 1.00 to 1.61), over the median level, were more likely to have hyperglycaemia compared with the remaining participants, after controlling for confounding factors.

Conclusions Hyperglycaemia was significantly and positively associated with increased serum soluble corin in men and women. Our findings suggest that serum soluble corin may be a risk factor or a biomarker of hyperglycaemia.

  • Serum soluble corin
  • Fasting plasma glucose

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2015-009085

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