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  • A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial)

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Infectious diseases
Protocol
A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial)

Authors

  • M J Grigg Global Health and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, AustraliaInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, KotaKinabalu, Sabah, Malaysia PubMed articlesGoogle scholar articles
  • T William Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, KotaKinabalu, Sabah, MalaysiaInfectious Diseases Unit, Clinical Research Centre, Queen Elizabeth Hospital, KotaKinabalu, Sabah, MalaysiaSabah Department of Health, KotaKinabalu, Sabah, Malaysia PubMed articlesGoogle scholar articles
  • P Dhanaraj Sabah Department of Health, KotaKinabalu, Sabah, MalaysiaKudat District Hospital, Kudat, Sabah, Malaysia PubMed articlesGoogle scholar articles
  • J Menon Sabah Department of Health, KotaKinabalu, Sabah, Malaysia PubMed articlesGoogle scholar articles
  • B E Barber Global Health and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, AustraliaInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, KotaKinabalu, Sabah, Malaysia PubMed articlesGoogle scholar articles
  • L von Seidlein Global Health and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, AustraliaMahidol-Oxford Research Unit, Bangkok, Thailand PubMed articlesGoogle scholar articles
  • G Rajahram Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, KotaKinabalu, Sabah, MalaysiaInfectious Diseases Unit, Clinical Research Centre, Queen Elizabeth Hospital, KotaKinabalu, Sabah, Malaysia PubMed articlesGoogle scholar articles
  • R N Price Global Health and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, AustraliaNuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • N M Anstey Global Health and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, AustraliaInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, KotaKinabalu, Sabah, MalaysiaDivision of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia PubMed articlesGoogle scholar articles
  • T W Yeo Global Health and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, AustraliaInfectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, KotaKinabalu, Sabah, MalaysiaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore PubMed articlesGoogle scholar articles
  1. Correspondence to Dr MJ Grigg; mat_grigg{at}hotmail.com
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Citation

Grigg MJ, William T, Dhanaraj P, et al
A study protocol for a randomised open-label clinical trial of artesunate-mefloquine versus chloroquine in patients with non-severe Plasmodium knowlesi malaria in Sabah, Malaysia (ACT KNOW trial)
BMJ Open 2014;4:e006005. doi: 10.1136/bmjopen-2014-006005

Publication history

  • Received June 30, 2014
  • Accepted July 17, 2014
  • First published August 19, 2014.
Online issue publication 
October 26, 2017

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/