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Is glaucoma comprehension associated with psychological disturbance and vision-related quality of life for patients with glaucoma? A cross-sectional study
  1. Xiang Mei Kong1,2,
  2. Wen Qing Zhu1,2,
  3. Jia Xu Hong1,2,
  4. Xing Huai Sun1,2,3
  1. 1Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China
  2. 2Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
  3. 3State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China
  1. Correspondence to Dr Xing Huai Sun; xinghuaisun{at}gmail.com

Abstract

Objective To investigate whether understanding of glaucoma is associated with psychological disturbance and vision-related quality of life (QoL) in patients with glaucoma.

Design A prospective, hospital-based, cross-sectional study.

Setting Shanghai, China.

Participants Five hundred patients with glaucoma were included in the study. Participants were asked to complete the glaucoma comprehension questionnaire, the Hospital Anxiety and Depression Scale (HADS) questionnaire, and the 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25).

Outcome measures Sociodemographic data and clinical data were collected. Multivariate adjusted linear regression analyses were performed to examine factors related to psychological disorder and QoL. The relationship between understanding of glaucoma and psychological status or QoL was analysed.

Results The mean age of patients was 56.5±17.2 years, and the mean duration of glaucoma was 4.6±6.3 years. About half (54.2%) of the patients had primary open angle glaucoma, 37.2% had primary angle closure glaucoma, and 8.6% had secondary glaucoma. The total score and the subscores of knowledge of glaucoma, compliance and habits were all negatively correlated with the HADS-Depression and HADS scores. For NEI VFQ-25, the total comprehension score was positively related to general vision, near activity, distance activity, social function, colour vision and the composite score. Habits had a significant influence on both HADS-Depression and the composite score of NEI VFQ-25.

Conclusions The level of understanding about glaucoma is an independent factor negatively associated with psychological disturbance and positively associated with QoL in patients with glaucoma. However, it is a subjective factor which can be regulated, so imparting knowledge about glaucoma and establishing appropriate habits might help patients alleviate psychological disturbance and enhance their QoL.

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Strengths and limitations of this study

  • This study for the first time highlights a novel factor which can be altered or improved so as to relieve psychological disturbance and improve the quality of life of patients with glaucoma.

  • Strengths of the study include the large sample with a high participation rate, control of confounding variables, and the use of several questionnaires.

  • The main weakness of the study is that it is hospital-based rather than population-based.

Introduction

Glaucoma is the second leading cause of blindness globally, after cataracts. However, because the blindness it causes is irreversible, glaucoma presents perhaps an even greater public health challenge than cataracts.1 Due to its asymptomatic, lifelong, chronic nature and potential outcome of blindness, it can often impose a psychological burden on patients.2 ,3 Anxiety and depression are two common forms of psychological disturbance and previous studies have shown that patients with glaucoma have a greater likelihood of having these conditions.4–6 Younger age, being female and having a moderate or heavy economic burden are risk factors for anxiety, while older age, increasing severity and duration of glaucoma are risk factors for depression.7 ,8 However, all these factors are objective and/or slow to change. Until now, to the best of our knowledge, few subjective factors have been shown to be associated with psychological disturbance in patients with glaucoma. In contrast to objective factors, subjective factors can change or be regulated. Thus, addressing subjective factors might alleviate the anxiety and depression of patients with glaucoma.

The term ‘quality of life’ (QoL) is a broad concept incorporating the patient's perspective of his or her health; it also reflects the gap between a person's expectations and their present status.9 QoL was introduced to ophthalmology in the 1980s as an evaluation indicator. Compared with the general QoL evaluation tools, vision-related QoL measurements have been widely accepted as specifically reflecting the impact of visual function impairment on the individual.10 Maximising a patient's QoL has been one of the main goals of glaucoma treatment,11 since vision-related QoL is reduced by the condition.12 ,13 Previous studies on the factors influencing vision-related QoL among patients with glaucoma have focused mainly on clinical types, visual function,14 ,15 treatment regimen and self-management.16 However, there have been no studies on how to improve QoL among patients with glaucoma, and many unknown factors have yet to be explored.

Ignorance of the nature of illness can delay or prevent compliance with the treatment of many diseases including glaucoma,17–19 and poor adherence to treatment may lead to preventable vision loss. It has been reported that over half of the undiagnosed cases of glaucoma in the general population occur in regions with high medical standards.20 For those who had been diagnosed with glaucoma, over a third did not know or were not sure of their glaucoma type.21 Thus, it is important to improve understanding of glaucoma in patients with the condition. However, how to increase the understanding and knowledge of patients remains a problem. Education of patients might be an easy and effective solution. The Shanghai Glaucoma Club (SGC) has attempted to educate patients for more than 16 years.21 ,22 A previous study showed that club members had a better understanding of glaucoma and looked ‘happier’ than general patients.21 This suggests possible relationships between understanding of glaucoma and anxiety, depression and QoL. Therefore, this study aims to determine if level of understanding of glaucoma is associated with psychological disturbance and vision-related QoL in patients with glaucoma. Evidence of such relationships might suggest a way to alleviate psychological disturbance and enhance QoL among patients with glaucoma, which would be of great significance in the treatment of glaucoma.

Methods

Subjects

This prospective study enrolled patients with clinically diagnosed glaucoma who were scheduled for vision care at the Department of Ophthalmology of the Shanghai Eye, Ear, Nose, and Throat Hospital of Fudan University from July 2012 to November 2012. The inclusion criteria were Chinese-speaking adult patients (18 years old and above) with a glaucoma diagnosis based on typical glaucomatous cupping of the optic disc with compatible visual field defects detected by automated static perimetry (Humphrey Visual Field Analyzer 30-2; Humphrey Instruments, San Leandro, California, USA) in one or both eyes. This study included patients with primary open angle glaucoma (POAG), primary angle closure glaucoma (PACG) and secondary glaucoma (SG). The exclusion criteria were as follows: (1) any other coexisting ocular condition that could impair visual function (eg, a visually significant cataract, retinal or neural pathology); (2) incisional ocular surgery in the past 3 months or laser treatment in the past 1 month; (3) current use of a medicine that might cause psychological disturbance, such as oral β-blockers; and (4) disability in a visual field test due to cognitive impairment.

The study was approved by the ethics committee of the hospital and was conducted according to the tenets of the Declaration of Helsinki. All participants gave their written informed consent. The data were labelled with serial numbers and analysed in a manner that protected patient privacy.

Clinical assessment

All patients underwent a complete ophthalmologic examination including best-corrected visual acuity (BCVA), slit lamp biomicroscopy, tonometry, indirect ophthalmoscopy and visual field examination. BCVA was evaluated with Snellen equivalents, based on a standard refraction and testing protocol at a starting distance of 5 m. Intraocular pressure was measured using a Goldmann applanation tonometer (Haag-Streit 900; Haag Streit, Koeniz, Switzerland). Visual field analysis was performed with automated perimetry (Humphrey Instruments) using a 30-2 threshold program (HFA30-2) with the SITA Standard strategy. The mean deviation (MD) in the last HFA30-2 taken within 3 months of enrolment in this study was used to evaluate visual field loss.

General information including age, gender, educational level, living status and marital status, together with clinical information including the duration of glaucoma, type of glaucoma, length of membership of the SGC, glaucoma medication, previous laser treatment and previous surgical treatment were all recorded on a checklist.

Three questionnaires were administered to all subjects: a glaucoma comprehension questionnaire, a Chinese version of the Hospital Anxiety and Depression Scale (HADS), and the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). The subjects were requested to answer the questionnaire by themselves. The research staff explained the questionnaire to them and provided assistance when required. For participants who could not read due to poor eyesight, a research staff member read the questionnaire to them in a neutral and uniform manner and recorded their choices.

Evaluation of comprehension and understanding of glaucoma

The glaucoma comprehension questionnaire consisted of 20 questions pertaining to three categories: the level of knowledge about glaucoma, compliance with medication usage and follow-up, and life style and habits. Answers to each question were scored, and the scores were summed for each section (0–12, 0–12 and 0–7, respectively) and as a total (0–31). Higher scores meant better understanding of glaucoma. This questionnaire was introduced and used in our previous study and published with it.21

Evaluation of psychological disturbance

The HADS questionnaire was developed by Zigmond and Snaith23 to identify and quantify the two most common forms of psychological disturbance in physically ill patients: anxiety and depression. The original HADS was translated into Chinese Mandarin and has been validated in many studies.24 ,25 The HADS scale contains 14 questions graded on a four-point Likert scale (0–3). It consists of two subscales: HADS-anxiety (HADS-A) and HADS-depression (HADS-D). In each of the seven-item subscales, the minimum sum score is 0 and the maximum is 21. Higher scores indicate a higher level of depression and anxiety. In this study, patients with scores above 10 on the HADS-A and HADS-D were diagnosed as having anxiety and depression, respectively.4 ,7

25-item National Eye Institute Visual Function Questionnaire

The NEI VFQ-25 is a vision-related QoL instrument for patients, and the present study used the Chinese version of NEI VFQ-25 with an additional question.26 ,27 Since the response rate of item no. 14 was shown to be rather low in the Chinese population,26 according to the instructions in the manual we chose item A8 from the NEI VFQ-39 to serve as an appendix to item no. 14. If the statistical analysis showed a low response rate for item no. 14, the results of the appendix would be used to alleviate the impact of a high miss rate for item no. 14 on the validity and reliability of the entire questionnaire.

Twelve subscales were included in the questionnaire: general health, general vision, ocular pain, near activities, distance activities, social functioning, mental health, role difficulties, dependency, driving, colour vision and peripheral vision. Guidelines published by the NEI were followed in calculating the scale conversions and subscale scores. The subscales were scored on a range from 0 to 100. Higher NEI VFQ-25 scores indicated better QoL and less impairment.

Statistical analysis

Data were analysed using SPSS for Windows, V.17.0 (SPSS, Chicago, Illinois, USA). The mean scores and SDs together with the range of the scores were calculated for each subscale and composite score of the glaucoma comprehension questionnaire, HADS and NEI VFQ-25. To determine the relationship between comprehension and HADS and between comprehension and NEI VFQ-25, multiple linear regression analysis was carried out with HADS and NEI VFQ-25 subscores as dependent variables and cognitive level as the independent variable, adjusted with or without demographic and clinical features. For the comparison between different levels of comprehension, three categories were formed based on the scores: low (0–18), moderate (19–25) and high (26–31). ANOVA and the Bonferroni test were used to detect differences. We divided the samples into 10 dB cohorts of the MD of the HFA30-2 test. The vision level of eyes that could not be examined by the HFA30-2 test because of poor visual function was assigned an MD value of −34.0 dB. For statistical analysis, vision levels of counting fingers, hand motion, light perception and no light perception were assigned visual acuity values of 1/200, 0.5/200, 0.25/200 and 0.125/200, respectively, and visual acuity was converted into a logarithm of minimum angular resolution (logMAR) visual acuity. A p value of <0.05 was considered statistically significant.

Results

A total of 508 patients were enrolled in this study; as eight patients were excluded because of incomplete data, 500 patients with glaucoma were chosen as study participants. The proportion of valid data was 98.43%. Table 1 shows the demographic characteristics of these subjects. The sample consisted of 266 males and 234 females. The mean age of the included subjects was 56.46±17.22 years and 92.6% had reached a middle school or higher educational level. Most (93.8%) of the subjects were living with family, and 87.4% were married. The mean duration of glaucoma for all subjects was 4.64±6.30 years; 54.2% had POAG, 37.2% had PACG and 8.6% had SG. Regarding treatment, 85.4% had one or more types of medication, 15.8% had undergone laser treatment, and 44.8% had undergone surgical treatment.

Table 1

Sociodemographic and clinical characteristics of subjects

Mean scores for glaucoma comprehension, HADS and vision-related QoL

The mean score of total glaucoma comprehension was 21.30±5.78. For the subgroups, it was 7.30±3.27 for knowledge of glaucoma, 9.21±2.10 for compliance, and 4.79±1.48 for habits.

The mean scores of total HADS, HADS-A and HADS-D were 13.41±6.59, 6.12±3.64 and 7.29±4.18, respectively. The prevalence of patients with glaucoma experiencing anxiety and depression was 11.2% and 26.0%, respectively.

For NEI VFQ-25 subscales, the scores ranged from 20.01 for driving to 87.60 for colour vision, and the composite score was 70.60±15.38. Since the driving subscale had a high rate of missing data (350/500, 70.0%), we omitted this subscale in the calculation of the composite score and in further analysis, as suggested by previous research (see table 2).

Table 2

Scores for each subscale and total scale of the comprehension questionnaire, HADS and NEI VFQ-25 in all subjects

Regression analysis of psychological disturbance and vision-related QoL by glaucoma comprehension

The analyses showed that many of the variables such as age, gender, educational level, visual acuity, severity and duration of glaucoma showed relationships with HADS scores and NEI VFQ-25 scores, so other variables were controlled in order to investigate the relationship between glaucoma comprehension and HADS and NEI VFQ-25. Table 3 showed the complete result with or without adjustments for other variables. Total glaucoma comprehension and its three subtypes (knowledge of glaucoma, compliance and habits) were negatively correlated with HADS-D and total HADS. The higher the level of comprehension, the lower the level of depression. However, the level of comprehension showed no correlation with HADS-A. For NEI VFQ-25, the level of comprehension was positively correlated with general vision, near activity, distance activity, social function, colour vision and the composite score. The higher the level of comprehension, the higher the scores for these items. Understanding of glaucoma was not correlated with general health, ocular pain, mental health, role difficulties, dependency or peripheral vision.

Table 3

Multivariate linear regression of subscales of HADS and NEI VFQ-25 according to the comprehension of patients with glaucoma

Comparison of depression and the NEI VFQ-25 composite score by different levels of glaucoma comprehension

As the level of comprehension increased from low to high, the scores of HADS-D (p<0.001) and total HADS (p<0.001) decreased significantly (p<0.001), while the subscores of general vision (p<0.001), near activity (p<0.001), far activity (p<0.001) and the composite score (p<0.05) of NEI VFQ-25 increased dramatically (figures 1 and 2). The subtypes of comprehension were also categorised into low, moderate and high levels: knowledge of glaucoma (0–7, 8–10, 11–12), compliance (0–7, 8–10, 11–12) and habits (0–4, 5, 6–7). The differences among the three levels, between low versus moderate, between low versus high, and between moderate versus high, were analysed. Only compliance had a significant influence on the level of depression of the groups being compared. Knowledge and habits had a significantly different effect on depression in the low versus moderate and low versus high groups. Only habits had a statistically significant effect on the composite score in the low versus moderate groups (table 4).

Table 4

Comparison of the HADS-D score and NEI VFQ-25 composite score by different levels of the subtypes of comprehension

Figure 1

The association between level of comprehension and the subscores of the Hospital Anxiety and Depression Scale (HADS), HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) in Chinese patients with glaucoma. As the level of comprehension increased, the scores of HADS-D and total HADS decreased significantly (F=65.371, p<0.001; F=25.302, p<0.001, respectively), while the change in HADS-A was not significant (F=0.638, p=0.529).

Figure 2

The association between level of comprehension and four of the subscores of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) in Chinese patients with glaucoma. As the level of comprehension increased, the subscores of general vision (F=8.372, p<0.001), near activity (F=16.607, p<0.001), far activity (F=12.884, p<0.001) and the NEI VFQ-25 composite score (F=3.821, p<0.05) increased dramatically.

Factors influencing the comprehension of patients with glaucoma

The level of comprehension of patients with glaucoma was positively related to the duration of their glaucoma. The scores of all subtypes (knowledge of glaucoma, compliance and habits) and of total comprehension significantly increased as the duration of glaucoma increased (F=46.160, p<0.001). The comprehension score of SGC members was 25.34±3.73, much higher than that of non-SGC members, which was 19.01±5.48 (p<0.001). Being an SGC member had a significant effect on the level of comprehension of patients with glaucoma. The longer the membership of the SGC, the higher the comprehension score (F=39.676, p<0.001).

Discussion

This study demonstrated that the level of understanding of glaucoma is an independent factor for psychological disturbance and QoL among patients with glaucoma. The level of comprehension is negatively correlated with depression and positively correlated with QoL, which means the higher the level of comprehension, the lower the level of depression and the higher the QoL. Among the subtypes of comprehension, habits significantly influenced depression and the QoL composite score, while knowledge of glaucoma and compliance only influenced depression.

Patients with glaucoma may experience lack of glaucoma knowledge and psychological disturbance.4–6 ,21 However, few studies have investigated the relationship between glaucoma comprehension and psychological disturbance. Stryker et al28 studied the relationship between adherence and psychological status and found that non-adherent participants were more fatalistic and less optimistic than adherent participants. However, the authors only examined adherence. In this study, we focused on patients with glaucoma and studied glaucoma comprehension, psychological disturbance and relationships. The glaucoma comprehension questionnaire showed a mean score of total comprehension of 21.30±5.78 (ranging from 6 to 31). A total of 178 cases (35.6%) belonged to the group with a low level of comprehension. As the level of comprehension increased, the subscores of HADS-D and HADS significantly decreased (from 9.74 to 5.03 and from 15.88 to 10.90, respectively). Our study suggests that improving the comprehension of patients with glaucoma, for instance by educating them about the slow progression of glaucoma and the effectiveness of treatments to delay progression, could alleviate their psychological disturbance, especially depression.

In recent years, increasing attention has been paid to QoL. Because a human being is a whole unit, for lifelong chronic diseases such as glaucoma, we cannot focus only on the eyes and neglect the rest of the body. Glaucoma may affect a patient's QoL in several ways, through the psychological effects of diagnosis (eg, anxiety, depression, fear of blindness, fear of effects on other family members), the visual effects of glaucoma (eg, decreased visual field), the potential side effects of treatment (medical or surgical), and the financial effects (eg, cost of visits and treatment, loss of income because of absenteeism from work). The vision-related QoL of patients with glaucoma in different countries can be compared by using NEI VFQ-25. The composite score of Mandarin Chinese subjects in our study was 70.6±15.4, slightly higher than that of Taiwan Chinese (69.2±20.4)29 and Japanese participants (69.8±1.9),30 but lower than that of Greek (81.7±14.7)31 and Nigerian individuals (85.2±16.1).32 This indicates that, in China, patients with glaucoma have a moderate vision-related QoL. Moreover, the extent of visual field damage could influence QoL. In the present study, the NEI VFQ-25 composite scores in the mild, moderate and severe groups were 76.1±12.8, 69.5±14.1 and 64.6±17.2, respectively. In a Nigerian population, the corresponding scores were 92.0±6.8, 89.3±10.4 and 74.3±21.1.32 A study in Belgium found that the global NEI VFQ-25 score dropped from 90.7±8.1 to 86.1±8.7 to 71.5±19.3 in early, moderate and advanced POAG groups.33 These findings demonstrate that vision-related QoL decreases with visual field progression. In the current study, after different levels were adjusted for variables, the extent of comprehension was always an independent factor positively related to the NEI VFQ-25 composite score (β=0.4, p=0.002; β=0.5, p<0.001; β=0.4, p=0.006). This score increased from 68.52 in the low comprehension group to 73.20 in the high comprehension group. Our results suggest that early diagnosis and intervention is essential for patients with glaucoma, and that educating patients can help them establish good habits that might benefit their QoL.

After being told of their glaucoma diagnosis, 34% of patients reported at least a moderate fear of blindness.2 It has been suggested that more attention should be given to reducing fear of blindness in patients with glaucoma at diagnosis and over time.2 Our results showed that glaucoma comprehension was lowest at the early stage of diagnosis. Also, habits had the lowest score among the three subtypes, which significantly correlated with both HADS-D and the NEI VFQ-25 composite score. Thus, instead of merely informing the patients of their diagnosis, clinicians should enhance patients’ knowledge of this disease and thereby reduce undue worry and concern over the glaucoma diagnosis,34 and help them to establish appropriate habits. Various styles of health education could have a positive effect on relieving the fear of patients.34 In existence for over 17 years, the SGC is a successful model for the education of patients with glaucoma.22 Our previous report and the current study demonstrated significant differences in basic glaucoma knowledge between SGC members and general patients with glaucoma; SGC members had much better comprehension of glaucoma and self-management.21 It may be that people who joined the SGC had a more positive outlook on life and were more motivated to manage their condition. Nevertheless, in the absence of other methods, the SGC might be an effective model for improving patients’ knowledge of the disease and compliance with treatment.

Our findings also provided epidemiological data on anxiety and depression in Chinese patients with glaucoma. The prevalence of anxiety in Chinese patients with glaucoma (11.2%) was comparable to that of Japan (13.0%)4 and Turkey (9.6–14.0%).6 ,35 However, the prevalence of depression in our study (26.0%) was higher than that of Japan (10.9%)4 and Turkey (24.7%),35 and lower than that found in another study from Turkey (57.0%).6

This study was an initial exploration of the psychological status and QoL of Chinese patients with glaucoma and the potential ways to improve them. Caution should be exercised when interpreting the findings because of a number of limitations. First, this was a cross-sectional rather than a longitudinal study. Although the conclusions drawn were based on multivariate linear regression with adjustment for possible confounding factors, further large-scale studies with long-term follow-up should be performed to confirm these findings of associations between glaucoma comprehension, depression and QoL. Second, all patients in this study were recruited from a single academic eye institute, and all were of Chinese Han ethnicity. This might have caused selection bias and our results might not be generalisable to the entire adult Chinese population with glaucoma. Third, to further investigate the influence of comprehension, we categorised the comprehension scores into three levels. This artificial classification might have led to bias. In addition, although this study examined several factors that might affect psychological status and QoL, by no means were all potential variables included. In an effort to address these limitations, the study covered a relatively large, homogeneous sample with a broad age range and applied rigorous quality control procedures to ensure high participant response rates and quality data.

In summary, for a typical physical disease such as glaucoma, patients’ comprehension and understanding of their condition might be independently associated with psychological disturbance and vision-related QoL. Comprehension of glaucoma could be improved by education, which would help patients alleviate their psychological disturbance and enhance their vision-related QoL. Doctors should also pay attention to the patients’ comprehension of glaucoma through better education and communication with patients regarding their disease and effective guidance over the course of their treatment.

Acknowledgments

The authors wish to thank Dr Jian Gao for his valuable help with data statistics and interpretation.

References

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Footnotes

  • Contributors XMK: collection and analysis of data, drafting the manuscript and final approval of the version to be published. WQZ: collection and interpretation of data and final approval of the version to be published. JH: interpretation of data and final approval of the version to be published. XHS: conception and design of the study, revising the article critically for important intellectual content and final approval of the version to be published.

  • Funding The authors were supported by the National Science and Technology Infrastructure Program (No. 2012YQ12008003) and Shanghai Health Systems Appropriate Technology Projects (2013SY058).

  • Competing interests None.

  • Ethics approval The ethics committee of the Eye and ENT Hospital, Shanghai Medical College approved this study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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