BMJ Open 4:e004538 doi:10.1136/bmjopen-2013-004538
  • Obstetrics and gynaecology
    • Research

Maternal glucose level and body mass index measured at gestational diabetes mellitus screening and the risk of macrosomia: results from a perinatal cohort study

  1. Ye She4
  1. 1Brock University, St. Catharines, Ontario, Canada
  2. 2Tianjin Women and Children's Health Center, Tianjin, China
  3. 3Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada
  4. 4Beichen Women and Children's Health Center, Tianjin, China
  1. Correspondence to Dr Jian Liu; jliu{at}
  • Received 23 November 2013
  • Revised 15 April 2014
  • Accepted 29 April 2014
  • Published 20 May 2014


Objective To examine the impact of maternal blood glucose (BG) level and body mass index (BMI) measured at gestational diabetes mellitus (GDM) screening on the risk of macrosomia.

Design A perinatal cohort of women were followed up from receiving perinatal healthcare to giving birth.

Setting Beichen District, Tianjin, China between June 2011 and October 2012.

Participants 1951 women aged 19–42 years with valid values of BMI and BG level at GDM screening (24–28 weeks gestation), singleton birth and birth weight (BW)>2500 g.

Main outcomes and measures Primary outcome was macrosomia (BW>4000 g). BG level and BMI were measured at GDM screening.

Results 191 (9.7%) newborns were macrosomia. The ORs (95% CIs) of macrosomia from multiple logistic regression were 1.14 (1.10 to 1.19, p<0.0001) for BMI and 1.11 (1.01 to 1.23, p=0.03) for BG. When BMI and BG levels (continuous) were modelled simultaneously, the OR for BMI was similar, but significantly attenuated for BG. Areas of receiver operating characteristics (ROC) were 0.6530 (0.6258 to 0.6803) for BMI and 0.5548 (0.5248 to 0.5848) for BG (χ2=26.17, p<0.0001). BG (mmol/L, <6.7, 6.7–7.8 or ≥7.8) and BMI in quintiles (Q1–Q5) were evaluated with BG <6.7 and Q2 BMI as the reference group. The ORs of macrosomia were not statistically different for mothers in Q1 or Q2 of BMI regardless of the BG levels; the ORs for ≥Q3 of BMI were elevated significantly with the highest OR observed in Q5 of BMI and BG levels ≥7.8 (6.93 (2.61 to 18.43), p<0.0001).

Conclusions High BMI measured at GDM screening was the most important determinant for risk of macrosomia. These findings suggest that GDM screening may be a critical gestational time point to initiate maternal weight control oriented intervention strategy to lower the risk.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

blog comments powered by Disqus