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  • Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case–control study protocol (LOD-Hipertensión)

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Cardiovascular medicine
Protocol
Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case–control study protocol (LOD-Hipertensión)
  1. Manuel A Gomez-Marcos1,2,
  2. Rogelio Gonzalez-Sarmiento3,
  3. José I Recio-Rodríguez1,
  4. Cristina Agudo-Conde1,
  5. Luis Gamella-Pozuelo3,
  6. Nuria Perretta-Tejedor4,
  7. Carlos Martínez-Salgado4,
  8. Luis García-Ortiz1,2
  1. 1Instituto de Investigación Biomédica de Salamanca (IBSAL). Primary Care Research Unit, La Alamedilla Health Center, Castilla and León Health Service–SACYL, Salamanca, Spain
  2. 2Medicine Department, University of Salamanca, Salamanca, Spain
  3. 3Instituto de Investigación Biomédica de Salamanca (IBSAL) and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), University of Salamanca–CSIC-SACYL, Salamanca, Spain
  4. 4Renal and Cardiovascular Pathophysiology Unit, Department of Physiology and Pharmacology, Instituto de Investigación Biomédica de Salamanca (IBSAL), Instituto Reina Sofía de Investigación Nefrológica, University of Salamanca, Salamanca, Spain
  1. Correspondence to Dr Manuel Angel Gómez Marcos; magomez{at}usal.es

Abstract

Introduction Target organ damage (TOD) is associated with increased cardiovascular risk. The study objectives were to analyse the relationship of TOD to blood pressure, size of retinal arteries and veins, oxidative stress and different polymorphisms in the VAV-2 and VAV-3 genes in participants with hypertension.

Methods and analysis A case–control study to analyse the relationship between clinical, biochemical and genetic parameters and presence of cardiac, vascular and renal TOD in 486 patients with hypertension. Participants with TOD will be considered as cases, and those without TOD will be enrolled as controls. This will be a collaborative study conducted by the groups of Primary Care, Cardiovascular and Metabolic and Degenerative Diseases of the Instituto de Investigación Biomédica of Salamanca (IBSAL). Assessment of cardiac, renal and vascular TOD. Measurement of peripheral and central blood pressure, size of eye fundus arteries and veins, and oxidative stress, and polymorphisms in the VAV-2 and VAV-3 genes.

Ethics and dissemination The study will be conducted after approval is obtained from the Ethics Committee of Hospital Clínico Universitario of Salamanca. All study participants will sign an informed consent to agree to participate in the study, and another consent to agree on the genetic study, in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow for an understanding of the relationship of the different TODs with blood pressure, retinal artery and vein diameters, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes.

Trial registration number Clinical Trials. gov Identifier: NCT02022618.

  • Target organ damage
  • Blood pressure
  • Retinal arteries and veins
  • Oxidative stress
  • Polymorphisms.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

https://doi.org/10.1136/bmjopen-2014-005112

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