Article Text


Reoperation after oesophageal cancer surgery in relation to long-term survival: a population-based cohort study
  1. Maartje van der Schaaf1,
  2. Maryam Derogar1,
  3. Asif Johar1,
  4. Martin Rutegård1,
  5. James Gossage2,
  6. Robert Mason2,
  7. Pernilla Lagergren1,
  8. Jesper Lagergren1,2,3
  1. 1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
  2. 2Department of Surgery, St Thomas’ Hospital, London, UK
  3. 3Division of Cancer Studies, King's College London, London, UK
  1. Correspondence to Dr Maartje van der Schaaf; maartje.van.der.schaaf{at}


Objectives The influence of reoperation on long-term prognosis is unknown. In this large population-based cohort study, it was aimed to investigate the influence of a reoperation within 30 days of oesophageal cancer resection on survival even after excluding the initial postoperative period.

Design This was a nationwide population-based retrospective cohort study.

Setting All hospitals performing oesophageal cancer resections during the study period (1987–2010) in Sweden.

Participants Patients operated for oesophageal cancer with curative intent in 1987–2010.

Primary and secondary outcomes Adjusted HRs of all cause, early and late mortality up to 5 years after reoperation following oesophageal cancer resection.

Results Among 1822 included patients, the 200 (11%) who were reoperated had a 27% increased HR of all-cause mortality (adjusted HR 1.27, 95% CI 1.05 to 1.53) and 28% increased HR of disease-specific mortality (adjusted HR 1.28, 95% CI 1.04 to 1.59), compared to those not reoperated. Reoperation for anastomotic insufficiency in particular was followed by an increased mortality (adjusted HR 1.82, 95% CI 1.19 to 2.76).

Conclusions This large and population-based nationwide cohort study shows that reoperation within 30 days after primary oesophageal resection was associated with increased mortality, even after excluding the initial 3 months after surgery. This finding stresses the need to consider any actions that might prevent complications and reoperation after oesophageal cancer resection.

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Strengths and limitations of this study

  • The study had a population-based cohort design.

  • It was possible to adjust for several confounding factors through comprehensive data collection from medical records and registries.

  • Data on complications other than reoperation were missing.

  • The retrospective design was a limitation.


Despite recent developments in multimodal therapy, surgical tumour resection is still the mainstay of treatment for localised oesophageal cancer.1 While postoperative mortality has decreased to less than 5% in recent years,2 oesophageal resection still carries a considerable risk for postoperative complications, some of which require reoperation.1 ,3 ,4 Major postoperative complications are known to negatively influence short-term survival,2 but evidence of the influence of such complications on long-term survival is inconsistent.5–8 A recent study from our group suggested that surgical complications after oesophageal cancer resection might be an independent predictor for a poorer long-term survival.9 Any potential effect of reoperation in lowering long-term survival after oesophagectomy could be mediated by several biological mechanisms, for example, the additional surgical trauma could further trigger an inflammatory response that could lower the efficacy of bodily defence mechanisms, including destruction and removal of circulating tumour cells, and thus pave the way for early recurrence,10 and the major surgical complications that cause the need for reoperation might directly facilitate tumour recurrence, for example, anastomotic insufficiency might entail direct tumour spread.9 ,11 Therefore, we hypothesised that reoperation within 30 days after initial oesophageal resection negatively influences long-term survival.


Study design

This was a retrospective population-based cohort study. The study cohort has previously been presented in detail.12 ,13 All patients having undergone oesophagectomy for oesophageal cancer during the period 1987–2010 in Sweden were included in the study. Eligible patients were followed up until death or end of the study (28 February 2012), whichever occurred first.

Study population

Patients with oesophageal cancer were identified from the Swedish Cancer Registry, a registry with 98% nationwide coverage of patients with oesophageal cancer.14 ,15 Tumours of the gastric cardia were not included. Oesophageal cancer was defined by the diagnosis code 150.0, 150.8 and 150.9 in the seventh version of the International Classification of Diseases (ICD7). The identified patients were linked with the Swedish Patient Registry to include only those who underwent oesophageal resection in the final study cohort. Our group has recently reported that the Patient Registry has a positive predictive value of 99.6% for assessing oesophageal cancer resection.16 Detailed information on tumour characteristics and surgical details was acquired through manual scrutiny of medical records from the operation charts and histopathology reports, with accompanying referral notes, retrieved from all relevant hospitals throughout Sweden.12 ,13 One reviewer, who was kept blinded for the study outcome to ensure objectivity, reviewed all histopathological reports according to a predefined protocol to ensure uniformity. The accuracy of the histopathological review was assessed by two researchers who independently reviewed 100 patient records, showing high accuracy (>90% concordance).13 The Patient Registry was used to obtain information on reoperations after the primary oesophageal resection and on comorbidities. Detailed information about indications for reoperation was not available. To calculate survival time after oesophagectomy, dates of death were collected from the Swedish Causes of Death Registry. This register is complete and is updated continuously, facilitating the availability of accurate dates of death. The unique 10-digit Swedish personal identity number, assigned to every resident in Sweden since 1947,17 was used for linkage of individuals between registries and for identification of the patients’ hospital records.

Study exposure and outcome

The exposure was defined as any open or minimally invasive reoperation within 30 days of initial oesophageal cancer resection. Exposure was defined according to the Classification of Surgical Procedures. More specifically, reoperation was categorised as: (1) explorative laparotomy (ICD10 JAH00, JAK00), (2) explorative thoracotomy (ICD10 GAB13, GAB96, GAB10), (3) reoperation for bleeding (ICD10 JWE00, GWE00), (4) reoperation for anastomotic insufficiency (ICD10 JWF00, GWF00, DWF00, (5) reoperation for wound revision (ICD10 JWA00) or (6) reoperation for deep infection (ICD10 GWC00, GCW01, JWC00; table 1).

Table 1

Categorisation of the 248 reoperations within 30 days after initial surgery in a cohort of 1822 patients undergoing oesophagectomy between 1987 and 2010 in Sweden, with follow-up until 28 February 2012

The study outcomes were all-cause early-specific, late-specific and disease-specific mortality. ‘Early postoperative mortality’ was defined as any death occurring within 90 days of initial surgery, while ‘late mortality’ was defined as any death between 90 days and 5 years of the primary resection. ‘Disease specific mortality’ was defined as death of tumour recurrence occurring between 90 days and 5 years of surgery. If a cause of death included oesophageal cancer (diagnosis codes 150 according to ICD7) in the Swedish Causes of Death Registry, we assumed that patients died of tumour recurrence. We also analysed the impact of each of the most common types of reoperations on mortality between 90 days and 5 years of surgery in subgroup analyses. Since tumour recurrence is a less likely explanation for mortality 5 years and later after oesophageal cancer surgery, we decided to use 5 years as a cut-off.

Statistical analysis

Survival was calculated using the Kaplan-Meier method, and differences in survival between the survival curves of patients with and without reoperation were evaluated using the log-rank test. In a Cox proportional hazards regression model, HRs with 95% CIs were calculated, including adjustment for potential confounding factors in a multivariable model. In the Cox model, the proportionality assumption was tested. The factors adjusted for were nine known prognostic factors. They were categorised as follows: (1) age (categorised into three groups: <65, 65–75 or >75 years); (2) sex; (3) comorbidity (including any of the following: hypertension, ischaemic heart disease, cardiac failure, chronic obstructive pulmonary disease, asthma, diabetes, former cancer diagnosis, HIV, liver disease and renal disease; and categorised into three groups: none, one, or two or more); (4) tumour stage (classified according to the sixth version of the Union for International Cancer Control-TNM (tumour, node, metastasis) classification and categorised into four groups: 0–I, II, III or IV); (5) histological type of tumour (categorised into two groups: squamous cell carcinoma or adenocarcinoma); (6) neoadjuvant therapy (yes or no) data on the type of neoadjuvant therapy used, that is, chemoradiotherapy or chemotherapy, was not available, but in Sweden, the use of chemoradiotherapy has dominated whenever neoadjuvant therapy has been used; (7) surgical radicality (R0 or not R0); (8) surgeon volume (<9 or ≥9 per year) To avoid selecting a suitable cut-off for surgeon annual volume, we simply chose to use the median as the cut-off and (9) calendar period (1987–1996 or 1996–2005). We also considered lymph node harvest as a potential confounder, but this variable did not significantly influence the results (χ2 p value 0.687), and since there was a substantial rate of missing data on lymph node harvest, we decided not to include this variable in the final multivariable model. Information on comorbidities was obtained from the Swedish Patient Register, information on tumour stage and histological type of tumour, surgical radicality and neoadjuvant treatment was extracted from histopathological records and accompanying referral notes.16 Missing values in the covariates were treated as a separate group in the Cox regression model.18 A sensitivity analysis was performed to compare the impact of categorising missing as a separate group against removing these missing values from the analysis.

All statistical analyses were performed using STATA V.11 for Mac (STATAcorp College Station, Texas, USA).



Some 2195 patients were identified as eligible in the study cohort of patients with oesophageal cancer who underwent resection in Sweden during the study period. After exclusion of 373 patients (17%) for whom medical records were not available or exposure data were missing, 1822 (83%) patients remained for final analysis. Of these, 200 patients (11%) were exposed for reoperation (in total 248 reoperations) within 30 days of the primary oesophageal resection (table 1).

There were no major differences between the groups with and without reoperation regarding the distribution of sex, age, comorbidity, tumour stage, tumour histology, neoadjuvant therapy, hospital volume or calendar period (table 2). Among the 1484 patients who died during the entire study period, 1246 (84%) had documented tumour recurrence, which means that the all-cause mortality within 5 years closely mirrors disease-specific mortality. There were no missing values for reoperation (exposure) and missing values in covariates were missing at random. A sensitivity analysis was performed to compare the impact of categorising missing as a separate group against removing these missing values from the analysis, and the results were similar (data not shown). In the Cox model, the proportionality assumption was tested and the model satisfied the assumption.

Table 2

Characteristics of 1822 patients undergoing oesophagectomy between 1987 and 2010 in Sweden, with follow-up until 28 February 2012

Reoperation and risk of mortality

Among the 208 patients (11%) who died within 90 days of surgery, 54 (26%) underwent reoperation. Reoperation was a risk factor for 90-day mortality after adjustment for confounding factors (HR 3.05, 95% CI 2.22 to 4.17). Among the 1276 (79%) patients who died between 90 days and 5 years after surgery, 117 (10%) were reoperated. Among the 122 who died after 5 years of surgery, 5 (4%) were reoperated. The log-rank test comparing the Kaplan-Meier survival curves of patients with and without reoperation between 90 days and 5 years after surgery revealed a statistically significantly increased mortality in the reoperated group (p<0.0001; figure 1 and table 3).

Table 3

HR with 95% CIs of mortality after oesophagectomy with respect to occurrence of reoperation, based on 1822 patients undergoing oesophageal cancer surgery in 1987–2012 in Sweden

Figure 1

Kaplan–Meier survival curve for survival between 90 days and 5 years with respect to occurrence of reoperation among 1614 patients undergoing oesophageal cancer surgery in 1987–2010 in Sweden.

As presented in table 3, there was a 27% increased hazard of mortality during the period 90 days to 5 years after surgery after adjustment for all nine potential confounding factors (crude HR 1.22, adjusted HR 1.27, 95% CI 1.05 to 1.53; table 3). During the follow-up period, 954 (74%) patients died of reported tumour recurrence. The disease-specific mortality within 90 days and 5 years of surgery was increased by 28% among patients who were reoperated (adjusted HR 1.28, 95% CI 1.04 to 1.59; table 3). The proportional hazard assumption, tested using a non-zero slope, and time varying covariates were satisfied, and there were no statistically significant interaction effects with reoperation (data not shown).

Reoperation and risk of mortality—subgroup analyses of most common reoperations

In a subgroup analysis of the three most common types of reoperations, that is, exploratory laparotomy, reoperation for anastomotic insufficiency and wound revision, the point HRs were increased for each type of reoperation (table 4), and patients reoperated for anastomotic insufficiency in particular had a statistically significantly increased hazard of mortality (adjusted HR 1.82, 95% CI 1.19 to 2.76).

Table 4

HRs with 95% CIs of mortality between 90 days and 5 years in a subgroup analyses of the most common types of reoperations after oesophagectomy, based on 1822 patients undergoing oesophageal cancer surgery in 1987–2012 in Sweden


This is, to the best of our knowledge, the first study addressing reoperation in relation to late mortality after primary oesophageal cancer resection, and it revealed an increased long-term all-cause and disease-specific mortality in patients who underwent reoperation compared with those who did not. Patients who underwent reoperation due to anastomotic insufficiency experienced a particularly high hazard of mortality.

Among the strengths of this study is the population-based design in which most patients who underwent oesophageal cancer surgery in Sweden during 1987–2010 were included. The follow-up for mortality was complete by virtue of the availability of personal identity numbers for Swedish residents, together with the fully complete Swedish Causes of Death Registry. Another major strength is the possibility to adjust for several known prognostic factors, which reduces the risk of confounding. Moreover, the exposure and outcome were predefined, which reduces the risk of chance findings and decreases the risk of systematic errors owing to misclassification. Some limitations of the study require a discussion. The retrospective clinical data collection imposes a risk of misclassification and selection bias. The researchers involved in gathering the clinical information had, however, no link with the participating hospitals and were not involved in the patient care, which decreases these risks. A risk of residual confounding by known prognostic factors or confounding by unknown factors cannot be excluded in observational research due to the lack of randomisation. There was, for example, no access to information on preoperative performance status and nutritional status, which might have influenced the results.19 Another limitation was the lack of information on complications, and thus the indication for the reoperations. Although the long study period offered good statistical power, it also entailed a risk of bias by changes in surgical techniques and standards in patients’ care over time. To counteract such effects, we adjusted all HRs for calendar period. The limited rate of exposure to reoperation still meant that the exposure could not be further subcategorised because of power issues. Finally, the use of a cut-off of 30 days of surgery for assessing reoperation might result in missing later reoperations. However, we decided before the study was initiated to use a cut-off that was likely to be directly associated with the oesophagectomy, but was yet not too short. Since there is no agreed on cut-off for capturing early reoperations associated with surgery, we instead use a commonly used cut-off for short-term mortality, which is traditionally 30 days.

The finding of the prognostic role of reoperations after excluding the initial postoperative period is a novel finding that should encourage further research. It stresses the need for preventive measures to reduce the need for reoperation. In this population, the three most commonly performed types of reoperation were explorative laparotomy (19%), reoperation for anastomotic leak (17%) and wound revision (20%). The results of the subgroup analyses showed that especially patients undergoing reoperation for anastomotic insufficiency had an increased risk of mortality. There is some evidence that anastomotic insufficiency entails direct tumour spread and seeding of remaining viable tumour cells in patients with colon cancer.11 ,20 This might explain the higher mortality in patients with reoperation for anastomotic insufficiency.

Several studies have shown that a higher surgeon or hospital volume reduces postoperative mortality and morbidity.12 ,21–24 High volume surgery is facilitated by centralisation of the care for patients with oesophageal cancer. Centralisation might be an effective measure for prevention of severe postoperative complications. A recent study showed that patients with comorbidity that compromises the cardiovascular status leading to a compromised perfusion of organs (eg, hypertension, diabetes, congestive heart failure and renal failure) have a higher risk of anastomotic leak. This finding indicates that preoperative optimisation of the cardiovascular status might also decrease the risk of severe complications requiring reoperation.25 No previous studies have, to the best of our knowledge, addressed the influence of reoperations on long-term survival in patients with oesophageal cancer. However, the main indication for reoperation is the occurrence of severe postoperative complications, and a few previous studies have assessed the role of such complications on long-term survival. These have provided conflicting results; some studies have reported a worse long-term prognosis after surgical complications,7 ,9 medical complications,10 or concurrent surgical and medical complication,4 while others have not found any such effect.6 ,8 These differences might be due to the differences in classification of the severity of the complications and missing information on interventions.

One biological mechanism that might explain the decreased long-term survival after reoperation is that the additional surgical injury reduces the protection against seeding of tumour cells, including activation of natural killer cells and other anticarcinogenic factors.26 Furthermore, it is possible that additional surgery triggers an elevated inflammatory response that might in turn stimulate the growth of microtumours and induce tumour recurrence and death from recurrence.10 Another potential mechanism considers certain complications. Finally, blood transfusion has been linked with a worse long-term mortality and increased cancer recurrence in different types of cancer.27–30 Unfortunately, we did not have information on blood transfusion in this study, but it can be assumed that patients returning to theatre are more likely to receive blood transfusion, and speculatively, blood transfusion may be a mechanism that contributes to the main finding of this study.

In conclusion, this nationwide and population-based cohort study with adjustment for several potential confounding factors indicates that reoperation is associated with an increased hazard of mortality even after the initial 3 months of the oesophageal cancer resection. This finding warrants more research, but further stresses the need to consider any actions that might prevent complications requiring reoperation after the primary surgery in patients with oesophageal cancer.


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  • Contributors MvdS and JL had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. MvdS, JL, PL, MR and MD were involved in the study concept and design. PL, JL, MvdS and MD contributed to the acquisition of data. MvdS, JL and AJ contributed to the analysis and interpretation of data. MvdS and JL were involved in the drafting of the manuscript. JG, RMM, MR and PL were involved in the critical revision of the manuscript for important intellectual content. AJ and MD conducted statistical analysis. JL and PL obtained funding.

  • Funding This study was funded by the Swedish Cancer Society (grant number 521-2012-3241) and the Swedish Research Council (grant number 12-0748).

  • Competing interests None.

  • Ethics approval The Regional Ethical Review Board in Stockholm, Sweden approved the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Statistical codes and the dataset are available from the primary investigator JL ( at the Upper GI Research Group, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm Sweden, who will provide a permanent and citable home for the dataset.

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