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BMJ Open 3:e002540 doi:10.1136/bmjopen-2012-002540
  • Paediatrics
    • Research

Nodding syndrome in Ugandan children—clinical features, brain imaging and complications: a case series

  1. James K Tumwine1
  1. 1Department of Paediatrics, Mulago Hospital/Makerere University College of Health Sciences, Kampala, Uganda
  2. 2Nuffield Department of Medicine, Centre for Tropical Medicine, Oxford University, Oxford, UK
  3. 3Department of Psychiatry, Mulago Hospital/Makerere University College of Health Sciences, Kampala, Uganda
  4. 4Department of Internal Medicine, Mulago Hospital/Makerere University College of Health Sciences, Kampala, Uganda
  5. 5Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children, London, UK
  6. 6Department of Neuroradiology, Great Ormond Street Hospital for Children, London, UK
  7. 7Department of Community Health and Family Medicine, Mulago Hospital/Makerere University College of Health Sciences, Kampala, Uganda
  8. 8Ministry of Health Head Quarters, Kampala, Uganda
  1. Correspondence to Dr Richard Idro; ridro1{at}gmail.com
  • Received 27 December 2012
  • Revised 5 April 2013
  • Accepted 8 April 2013
  • Published 3 May 2013

Abstract

Objectives Nodding syndrome is a devastating neurological disorder of uncertain aetiology affecting children in Africa. There is no diagnostic test, and risk factors and symptoms that would allow early diagnosis are poorly documented. This study aimed to describe the clinical, electrophysiological and brain imaging (MRI) features and complications of nodding syndrome in Ugandan children.

Design Case series.

Participants 22 children with nodding syndrome brought to Mulago National Referral Hospital for assessment.

Outcome measures Clinical features, physical and functional disabilities, EEG and brain MRI findings and a staging system with a progressive development of symptoms and complications.

Results The median age of symptom onset was 6 (range 4–10) years and median duration of symptoms was 8.5 (range 2–11) years. 16 of 22 families reported multiple affected children. Physical manifestations and complications included stunting, wasting, lip changes and gross physical deformities. The bone age was delayed by 2 (range 1–6) years. There was peripheral muscle wasting and progressive generalised wasting. Four children had nodding as the only seizure type; 18 in addition had myoclonic, absence and/or generalised tonic–clonic seizures developing 1–3 years after the onset of illness. Psychiatric manifestations included wandering, aggression, depression and disordered perception. Cognitive assessment in three children demonstrated profound impairment. The EEG was abnormal in all, suggesting symptomatic generalised epilepsy in the majority. There were different degrees of cortical and cerebellar atrophy on brain MRI, but no hippocampal changes. Five stages with worsening physical, EEG and brain imaging features were identified: a prodrome, the development of head nodding and cognitive decline, other seizure types, multiple complications and severe disability.

Conclusions Nodding syndrome is a neurological disorder that may be characterised as probably symptomatic generalised epilepsy. Clinical manifestations and complications develop in stages which might be useful in defining treatment and rehabilitation. Studies of risk factors, pathogenesis, management and outcome are urgently needed.

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