Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease
- 1Haematology and Sickle Cell Centre, Central Middlesex Hospital, London, UK
- 2National Institute of Health and Clinical Excellence, Manchester, UK
- Correspondence to Dr Kofi A Anie; kofi.anie{at}nhs.net
- Received 7 April 2012
- Accepted 8 June 2012
- Published 2 July 2012
Abstract
Introduction Acute pain is a hallmark of sickle cell disease (SCD) for which frequent hospital admissions may be required, affecting the quality of life of patients.
Objectives To characterise the relationship between adult patient self-reported sickle cell pain, mood and quality of life during and after hospital admissions.
Design Longitudinal study across three time-points.
Setting Secondary care, single specialist sickle cell centre.
Participants 510 adult patients with SCD admitted to hospital daycare or inpatient units.
Outcome measures Self-assessments of pain, mood and health-related quality of life with health utility (measured on the EQ-5D) on admission, before discharge and at 1-week postdischarge.
Results Mood, general health and quality of life showed significant steady improvements with reduction of pain in patients with SCD on admission to hospital, before discharge and at 1-week follow-up (p<0.01). Health utility scores derived from the EQ-5D showed a negative association with pain in regression analysis over the three time-points.
Conclusion Examining health-related quality of life and health utility in relation to pain during hospital admissions is valuable in terms of targeting appropriate psychological interventions within the context of a multidisciplinary approach to managing sickle cell pain. This has implications for healthcare costs.
Footnotes
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To cite: Anie KA, Grocott H, White L, et al. Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease. BMJ Open 2012;2:e001274. doi:10.1136/bmjopen-2012-001274
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Contributors KAA conceived, designed the study and performed some statistical analyses. HG and LW were responsible for data collection and entry into the study database. GR and MD performed statistical analyses. GC was involved in the study oversight. KAA took the lead in the write up with review and editing by HG, GR, MD and GC. All authors read and approved the final manuscript.
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Funding This research received no specific grant from any funding agency in public, commercial or not-for-profit sectors.
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Competing interests KAA was a co-opted expert to the NICE Guideline Development Group for the Sickle Cell Acute Painful Episode. The authors declare that there is no support from any organisation for the submitted work, no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years and no other relationships or activities that could appear to have influenced the submitted work.
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Provenance and peer review Not commissioned; externally peer reviewed.
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Data sharing statement None.
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