You are here

  • Home
  • Archive
  • Volume 9, Issue 5
  • Prolonged infusion with β-lactam antibiotics for treatment of infection caused by non-susceptible bacteria: a study protocol for a systemic review and meta-analysis

Article Text

Article menu

Download PDFPDF

XML
Infectious diseases
Protocol
Prolonged infusion with β-lactam antibiotics for treatment of infection caused by non-susceptible bacteria: a study protocol for a systemic review and meta-analysis
  1. Huadong Chen1,
  2. Lingyan Yu2,
  3. Zhenwei Yu3
  1. 1 Department of Pharmacy, Dongyang People’s Hospital, Dongyang, Zhejiang, China
  2. 2 Department of Pharmacy, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
  3. 3 Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
  1. Correspondence to Dr Huadong Chen; chuadong666{at}163.com and Dr. Zhenwei Yu; yzw_srrsh{at}zju.edu.cn

Abstract

Introduction Prolonged infusion with β-lactam antibiotics should theoretically produce a better clinical efficacy than intermittent infusion in severe infection and infection caused by non-susceptible micro-organisms. The efficacy of prolonged infusion in severe infection has been well illustrated recently, but is still confusing in non-susceptible microbial infection. The objective of this meta-analysis is to determine the clinical effects of prolonged infusion with β-lactams for patients infected by microbes non-susceptible to the given drug.

Methods and analysis Literature searches will be performed with Medline, the Cochrane database, EMBASE database, Cumulative Index to Nursing and Allied Health Literature database, the Chinese National Knowledge Infrastructure and Wanfang database. Two reviewers will screen and select studies according to a priori defined eligibility criteria, and then the data from the included studies will be extracted. The quality will be evaluated based on a modified Jadad score and the Newcastle-Ottawa system for randomised controlled trials and observational studies, respectively. Data synthesis will be performed with Review Manager 5.3 software. Sensitivity analysis and publication bias will also be investigated.

Ethics and dissemination No ethics approval is required. The full article will be published in a peer-reviewed journal and presented at international conferences.

PROSPERO registration number CRD42018105111.

  • microbiology
  • infectious diseases
  • infection control
  • clinical pharmacology

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2018-027509

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors HC and ZY had the original idea for a meta-analysis. All authors designed the protocol. HC and ZY reviewed the search strategy. HC and LY drafted the protocol. ZY registered in PROSPERO and is the guarantor of the protocol. All authors read and approved the final version of the article.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Patient consent for publication Not required.