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  • Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol

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Paediatrics
Protocol
Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol
  1. Katrin A Dias1,
  2. Jeff S Coombes1,
  3. Daniel J Green2,3,
  4. Sjaan R Gomersall1,
  5. Shelley E Keating1,
  6. Arnt Erik Tjonna4,
  7. Siri Marte Hollekim-Strand4,
  8. Mansoureh Sadat Hosseini4,
  9. Torstein Baade Ro5,6,
  10. Margrete Haram7,
  11. Else Marie Huuse4,
  12. Peter S W Davies8,9,
  13. Peter A Cain10,
  14. Gary M Leong11,12,
  15. Charlotte B Ingul4
  1. 1School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, Queensland, Australia
  2. 2School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Western Australia, Australia
  3. 3Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
  4. 4Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
  5. 5Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
  6. 6Department of Pediatrics, St. Olav's University Hospital, Trondheim, Norway
  7. 7Department of Radiology, Trondheim University Hospital, Trondheim, Norway
  8. 8Children's Nutrition Research Centre, The University of Queensland, Brisbane, Queensland, Australia
  9. 9Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia
  10. 10Heart Care Partners, The Wesley Hospital, Brisbane, Queensland, Australia
  11. 11Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
  12. 12Department of Paediatric Endocrinology, Lady Cilento Children's Hospital, Brisbane, Queensland, Australia
  1. Correspondence to Dr Charlotte B Ingul; charlotte.b.ingul{at}ntnu.no

Abstract

Introduction The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous training (MICT) in adults with chronic disease and has been shown to induce a rapid reversal of subclinical disease markers in obese children and adolescents. The primary aim of this study is to compare the effects of HIIT with MICT on myocardial function in obese children and adolescents.

Methods and analysis Multicentre randomised controlled trial of 100 obese children and adolescents in the cities of Trondheim (Norway) and Brisbane (Australia). The trial will examine the efficacy of HIIT to improve cardiometabolic outcomes in obese children and adolescents. Participants will be randomised to (1) HIIT and nutrition advice, (2) MICT and nutrition advice or (3) nutrition advice. Participants will partake in supervised exercise training and/or nutrition sessions for 3 months. Measurements for study end points will occur at baseline, 3 months (postintervention) and 12 months (follow-up). The primary end point is myocardial function (peak systolic tissue velocity). Secondary end points include vascular function (flow-mediated dilation assessment), quantity of visceral and subcutaneous adipose tissue, myocardial structure and function, body composition, cardiorespiratory fitness, autonomic function, blood biochemistry, physical activity and nutrition. Lean, healthy children and adolescents will complete measurements for all study end points at one time point for comparative cross-sectional analyses.

Ethics and dissemination This randomised controlled trial will generate substantial information regarding the effects of exercise intensity on paediatric obesity, specifically the cardiometabolic health of this at-risk population. It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT on subclinical markers of disease.

Trial registration number NCT01991106.

  • Paediatric obesity
  • Myocardial function
  • Vascular function
  • Visceral adipose tissue
  • High intensity interval training
  • NUTRITION & DIETETICS

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2015-010929

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