You are here

  • Home
  • Archive
  • Volume 6, Issue 11
  • Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies

Article Text

Article menu

Download PDFPDF

XML
Research methods
Protocol
Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies
  1. Carlos Podalirio Borges de Almeida1,
  2. Rachel Couban2,
  3. Sun Makosso Kallyth3,
  4. Vagner Kunz Cabral1,
  5. Samantha Craigie2,
  6. Jason Walter Busse4,5,
  7. Denise Rossato Silva1,6
  1. 1Respiratory Sciences Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
  2. 2The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada
  3. 3The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada
  4. 4Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
  5. 5Department of Clinical Epidemiology & Biostatistics, The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada
  6. 6Faculty of Medicine, Pulmonology Division, Universidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
  1. Correspondence to Dr Carlos Podalirio Borges de Almeida; carlosalmeida1410{at}hotmail.com

Abstract

Introduction Tuberculosis (TB) continues to be a major public health issue worldwide, with 1.4 million deaths occurring annually. There is uncertainty regarding which factors are associated with in-hospital mortality among patients with pulmonary TB. This knowledge gap complicates efforts to identify and improve the management of those individuals with TB at greatest risk of death. The aim of this systematic review and meta-analysis is to establish predictors of in-hospital mortality among patients with pulmonary TB to enhance the evidence base for public policy.

Methods and analysis Studies will be identified by a MEDLINE, EMBASE and Global Health search. Eligible studies will be cohort and case–control studies that report predictors or risk factors for in-hospital mortality among patients with pulmonary TB and an adjusted analysis to explore factors associated with in-hospital mortality. We will use the Grading of Recommendations Assessment, Development and Evaluation approach to summarise the findings of some reported predictors. Teams of 2 reviewers will screen the titles and abstracts of all citations identified in our search, independently and in duplicate, extract data, and assess scientific quality using standardised forms quality assessment and tools tailored. We will pool all factors that were assessed for an association with mortality that were reported by >1 study, and presented the OR and the associated 95% CI. When studies provided the measure of association as a relative risk (RR), we will convert the RR to OR using the formula provided by Wang. For binary data, we will calculate a pooled OR, with an associated 95% CI.

Ethics and dissemination This study is based on published data, and therefore ethical approval is not a requirement. Findings will be disseminated through publication in peer-reviewed journals and conference presentations at relevant conferences.

Trial registration number CRD42015025755.

  • Pulmonary tuberculosis
  • Risk factors
  • Systematic review
  • Meta-analysis
  • Protocol
  • Mortality

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-011957

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors All authors made substantial contributions to conception and design. CPBdA designed the study, collected the data and wrote the manuscript. RC designed the search strategy. SMK designed the study and analysed the data. VKC collected the data and wrote the manuscript. SC designed the study and collected the data. JWB designed the study, analysed the data and wrote the paper. DRS designed the study, collected the data, and wrote the paper, as well as revised it critically for important intellectual content. All authors provided final approval of the version to be published.

    • Funding Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) Fundo de Incentivo à Pesquisa (FIPE)/Hospital de Clínicas de Porto Alegre.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.