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Oncology
Research
Prognostic role of microRNA-205 in multiple human malignant neoplasms: a meta-analysis of 17 studies
  1. Jia-yi Zhang1,
  2. Meng-yan Sun2,
  3. Ning-hong Song1,
  4. Zhong-lei Deng3,
  5. Chun-yu Xue2,
  6. Jie Yang1
  1. 1From Department of Urology, The First Affiliated Hospital Of Nanjing Medical University, Nanjing, Jiangsu, China
  2. 2From Department of Plastic Surgery, Changhai Hospital Affiliated To Second Military Medical University, Shanghai, China
  3. 3From Department of Urology, Affiliated Hospital Of Nanjing Medical University Of TCM, Nanjing, Jiangsu, China
  1. Correspondence to Dr Jie Yang; yj197912{at}163.com

Abstract

Objective MicroRNA-205 (miRNA-205) was revealed as an attractive prognostic tumour biomarker in recent studies. However, the results of different studies have been inconsistent. We conducted a meta-analysis to elucidate the precise predictive value of miRNA-205 in various human malignant neoplasms.

Design Meta-analysis.

Data sources Qualified studies were identified up to 5 June 2014 by performing online searches in PubMed, EMBASE and Web of Science, and additional quality evaluations.

Participants Seventeen eligible studies with 4827 patients were ultimately enrolled in this meta-analysis.

Outcome measures The heterogeneity between studies was assessed using I2 statistics. Pooled HRs with 95% CIs for patient survival and disease recurrence were calculated to investigate the correlation between miRNA-205 expression and cancer prognosis.

Results Our results indicate that elevated miRNA-205 was significantly associated with enhanced overall survival in the breast cancer subgroup (HR=0.78, 95% CI 0.67 to 0.91) and superior disease-free survival/recurrence-free survival in the adenocarcinoma subgroup (HR=0.68, 95% CI 0.49 to 0.94).

Conclusions miRNA-205 is a promising biomarker for predicting the recurrence and progression of patients with adenocarcinomas or breast cancer. Owing to its complex roles, further relevant studies are warranted.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2014-006244

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