You are here

Article Text

Article menu

Download PDFPDF

XML
Cardiovascular medicine
Research
Nocturnal hypoxaemia in patients with Eisenmenger syndrome: a cohort study
  1. Sivasubramanian Ramakrishnan1,
  2. Rajnish Juneja1,
  3. Neil Bardolei1,
  4. Ajay Sharma1,
  5. Garima Shukla2,
  6. Manvir Bhatia2,
  7. Mani Kalaivani3,
  8. Shyam S Kothari1,
  9. Anita Saxena1,
  10. Vinay K Bahl1,
  11. Randeep Guleria4
  1. 1Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
  2. 2Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
  3. 3Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
  4. 4Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Dr Rajnish Juneja; rjuneja2{at}gmail.com

Abstract

Objectives The objective of the study was to find the prevalence of sleep-related disturbances in patients of Eisenmenger syndrome.

Design Prospective observational study.

Setting Tertiary care referral centre in North India.

Participants The study included 25 patients with Eisenmenger syndrome (mean age 25.2±9.6 years, 18 men) and 12 patients with cyanotic congenital heart disease with pulmonary stenosis physiology (mean age 20.5±8.5 years, 8 men) as controls.

Interventions All the patients underwent an overnight comprehensive polysomnogram study and pulmonary function testing.

Main outcome measure Oxygen desaturation index, which is the number of oxygen drops per hour.

Results The patients and controls had significant nocturnal hypoxaemia in the absence of apnoea and hypopnoea. The mean oxygen drop index in Eisenmenger syndrome group was 9.0±6.2 and in the control group was 8.0±5.9 (p=0.63). The apnoea–hypopnoea index was 3.37±5.0 in the Eisenmenger syndrome group and was 2.1±3.6 in the control group. Patients with >10 oxygen drops per hour had significantly higher haemoglobin (17.2±1.3% vs 14.4±1.5%, p<0.001) than those with oxygen drops less than 10.

Conclusions Eisenmenger syndrome patients have significant nocturnal hypoxaemia unrelated to hypopnoea and apnoea. Nocturnal desaturation occurred more frequently in patients with greater haemoglobin values.

  • SLEEP MEDICINE

this is an open-access article distributed under the terms of the creative commons attribution non-commercial license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. see: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

https://doi.org/10.1136/bmjopen-2012-002039

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text