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HIV/AIDS
Protocol
Effectiveness of non-pharmacological interventions to decrease fatigue in people living with HIV/AIDS: a protocol of systematic review and meta-analysis
  1. Xueling Xiao1,2,
  2. Nancy R Reynolds2,
  3. Leorey Saligan3,
  4. Yunxiao Lei4,
  5. Min Wang5,
  6. Honghong Wang1
  1. 1Xiangya Nursing School, Central South University, Changsha, Hunan, China
  2. 2School of Nursing, Johns Hopkins University, Baltimore, Maryland, USA
  3. 3National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland, USA
  4. 4School of Nursing, Henan University of Science and Technology, Luoyang, Henan, China
  5. 5HIV/AIDS Department, First Hospital of Changsha, Changsha, Hunan, China
  1. Correspondence to Professor Min Wang; wangmin2828{at}163.com

Abstract

Introduction Fatigue is a common symptom among people living with HIV (PLWH). It has a substantial adverse impact on functional status and the ability to conduct activities of daily living. Identifying effective strategies to prevent or reduce fatigue is significant to promote the quality of life of this vulnerable population. The purpose of this review is to synthesise the non-pharmacological evidence and assess the effects of interventions on reducing HIV-related fatigue among PLWH.

Methods and analysis We will comprehensively search literature available up to 30 June 2020, in the following databases: PubMed, Embase, CINAHL, Cochrane Library, Web of Science and PsycINFO. The reference list of selected studies and relevant published reviews will also be screened to retrieve potential articles. Two reviewers will identify the eligible articles, extract data and identify the biases in the selected studies. Any disagreements will be referred to a third reviewer. We will qualitatively synthesise the evidence and pool data with meta-analysis according to the heterogeneity of different studies.

Ethics and dissemination This systematic review will not raise any ethical issues since it is a secondary data collection and analysis. The results will inform effective strategies to reduce fatigue among PLWH. The final report will be published in a peer-reviewed journal and academic conferences.

PROSPERO registration number CRD42020153715.

  • HIV & AIDS
  • primary care
  • infectious diseases
  • public health
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2020-040996

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    Footnotes

    • Contributors XX and MW initiated the idea and led the development of the protocol. YL contributed to the methodology development. HW, NRR, MW and LS critically reviewed intellectual content and revised successive drafts of the manuscripts. HW and NRR provided supervision to XX. All the authors approved the publication of the protocol.

    • Funding This work is financially supported by Innovation-driven project of Central South University (Grant No: 2018zzts244) and China Scholarship Council (Grant No. 201806370164). No other assistance was provided by the funders during the whole process of developing the protocol.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.