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Public health
Protocol
Study protocol for the systematic review and meta-analyses of the association between schizophrenia and bone fragility
  1. Behnaz Azimi Manavi1,
  2. Amanda L Stuart1,
  3. Julie A Pasco1,2,
  4. Jason M Hodge1,3,
  5. Kayla Corney1,
  6. Michael Berk1,4,5,6,7,
  7. Lana J Williams1
  1. 1Deakin University, IMPACT – Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia
  2. 2Clinical and Biomedical Sciences: Barwon Health, University of Melbourne School of BioSciences, Melbourne, Victoria, Australia
  3. 3Geelong Centre for Emerging Infectious Diseases (GCEID), Barwon Health, Geelong, Victoria, Australia
  4. 4University of Melbourne, Department of Psychiatry, Royal Melbourne Hospital, Parkville, Victoria, Australia
  5. 5Florey Institute for Neuroscience and Mental Health, University of Melbourne, RoyalMelbourne Hospital, Parkville, Victoria, Australia
  6. 6Centre of Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
  7. 7Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia
  1. Correspondence to Ms Behnaz Azimi Manavi; bazimimanavi{at}deakin.edu.au

Abstract

Introduction Individuals with schizophrenia are known to be at higher risk of comorbid conditions, both physical and psychological. Osteoporosis is possibly one of these, leading to public health concerns due to higher rates of associated mortality and morbidity. We aim to systematically search all available evidence across electronic databases regarding the relationship between schizophrenia and bone fragility.

Methods and analysis A systematic search of the research databases CINAHL, MEDLINE Complete, Embase and PsycINFO will be conducted and identified papers reviewed for eligibility, with a second reviewer confirming inclusions. Searches will be run from database inception to 1 October 2020 and supplemented by the hand checking of references of identified articles. A previously published scoring system will be used for assessing the methodological quality and risk of bias. A meta-analysis is planned.

Ethics and dissemination Due to including published literature only, ethical permission will not be necessary. Results of this study will be published in a relevant scientific journal and presented at a conference in the field of interest.

PROSPERO registration number CRD42020171959.

  • schizophrenia
  • osteoporosis
  • osteopenia
  • fracture
  • bone density
  • bone fragility
  • bone quality
  • bone health
  • mental disorders
  • psychiatry
  • neuroscience
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2020-041859

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    Footnotes

    • Contributors BAM, JAP and LJW conceptualised the research question for this protocol. ALS, JMH, KC and MB revised and edited the research question. The search strategy was developed by BAM, JAP and LJW and reviewed by a librarian (BK). The methodological processes have been revised and approved by all authors (BAM, ALS, JAP, JMH, KC, MB and LJW). BAM and LJW drafted this manuscript. All authors (BAM, ALS, JAP, JMH, KC, MB and LJW) read, edited and approved the final version and guarantee the review.

    • Funding The study is supported by the National Health and Medical Research Council (NHMRC), Australia (1162867). BAM is supported by Deakin University Postgraduate Research Scholarship (DUPRS), KC is supported by an Australian Rotary Health/Bing Taylor PhD Scholarship, MB is supported by an NHMRC Senior Principal Research Fellowship (1156072) and LJW is supported by an NHMRC Career Development Fellowship (1064272) and an NHMRC Investigator grant (1174060).

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.