Article Text
Abstract
Introduction Smoking prior to major thoracic surgery is the biggest risk factor for development of postoperative pulmonary complications, with one in five patients continuing to smoke before surgery. Current guidance is that all patients should stop smoking before elective surgery yet very few are offered specialist smoking cessation support. Patients would prefer support within the thoracic surgical pathway. No study has addressed the effectiveness of such an intervention in this setting on cessation. The overall aim is to determine in patients who undergo major elective thoracic surgery whether an intervention integrated (INT) into the surgical pathway improves smoking cessation rates compared with usual care (UC) of standard community/hospital based NHS smoking support. This pilot study will evaluate feasibility of a substantive trial.
Methods and analysis Project MURRAY is a trial comparing the effectiveness of INT and UC on smoking cessation. INT is pharmacotherapy and a hybrid of behavioural support delivered by the trained healthcare practitioners (HCPs) in the thoracic surgical pathway and a complimentary web-based application. This pilot study will evaluate the feasibility of a substantive trial and study processes in five adult thoracic centres including the University Hospitals Birmingham NHS Foundation Trust. The primary objective is to establish the proportion of those eligible who agree to participate. Secondary objectives include evaluation of study processes. Analyses of feasibility and patient-reported outcomes will take the form of simple descriptive statistics and where appropriate, point estimates of effects sizes and associated 95% CIs.
Ethics and dissemination The study has obtained ethical approval from NHS Research Ethics Committee (REC number 19/WM/0097). Dissemination plan includes informing patients and HCPs; engaging multidisciplinary professionals to support a proposal of a definitive trial and submission for a full application dependent on the success of the study.
Trial registration number NCT04190966.
- cardiothoracic surgery
- adult thoracic medicine
- adult anaesthesia
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Footnotes
Collaborators The Project MURRAY Investigators: Michael Shackcloth, Sarah Feeney, Lindsey Murphy, Magenta Black, Sridhar Rathinam, Rebecca Boyles, Syed Qadri, Karen Dobbs, Helen Shackleford, Zara Jalal, Christine Jordan, Christopher Golby, Ben Skirth.
Contributors All authors have made substantial contributions to the conception or design of the work, or acquisition, analysis or interpretation of the data. STL has participated in the study design, intervention development and drafted the manuscript. SK, AK and A-MB have participated in the intervention development. AF, OP, JB, RW, DRT and BN have participated in the study design, intervention development and have critically revised the manuscript. All authors have approved the final version.
Funding The research costs of the trial are funded by an investigator-initiated study grant from Johnson and Johnson (Grant #IIS-ENG-2017-01).
Competing interests None declared.
Patient and public involvement Patients and/or the public were involved in the design, or conduct, or reporting or dissemination plans of this research. Refer to the Trial design section for further details.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.